BPPA MF: C30H36N4O4*2CH3COOH
MW: 637.00
A potent, novel and selective inhibitor of human telomerase.

BPPA

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Synonym: 2,6-bis(3-Piperidinopropionamido)anthraquinone diacetate
Application: A potent, novel and selective inhibitor of human telomerase
Purity: 97%
Molecular Weight: 637.00
Molecular Formula: C30H36N4O4*2CH3COOH
* Refer to Certificate of Analysis for lot specific data (including water content).
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BPPA is a potent, novel and selective inhibitor of human telomerase that has displayed strong cytotoxic activity against human carcinoma cell lines through a mechanism of action unrelated to telomerase inhibition.


References

1. Perry, P.J., et al. 1998. J. Med. Chem. 41: 3253-3260. PMID: 9703471

Physical State :
Solid
Solubility :
Soluble in water (110 mg/ml), DMSO (20 mg/ml), and ethanol (2 mg/ml).
Storage :
Store at -20° C
IC50 :
Telomerase : IC50 = 4.5 µM (human); Inhibit SKOV-3-cell growth: IC50 = 2.1 µM; Inhibit CH1-cell growth: IC50 = 14.5 µM; Inhibit A2780-cell growth: IC50 = 2.45 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
374316
SMILES :
CC(=O)O.C1CCN(C(C1)CO)CCC(=O)NC2=CC3=C(C=C2)C(=O)C4=C(C3=O)C=CC(=C4)NC(=O)CCN5CCCCC5CO

Download SDS (MSDS)

Certificate of Analysis

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