Molecular structure of TMPyP4, CAS Number: 36951-72-1
TMPyP4 (CAS 36951-72-1)
See product citations (9)
Alternate Names:
meso-Tetra (N-methyl-4-pyridyl) porphine tetra tosylate
Application:
TMPyP4 is a potent inhibitor of telomerase activity
CAS Number:
36951-72-1
Purity:
≥90%
Molecular Weight:
1363.60
Molecular Formula:
C44H38N8•C28H28O12S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TMPyP4, tetra-(N-methyl-4-pyridyl)porphyrin, is a potent inhibitor of human TERT (telomerase, IC50 = 6.5 muM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. TMPyP4 fluoresces intensely in the presence of quadruplex DNA.
TMPyP4 (CAS 36951-72-1) References
- Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. | Shi, DF., et al. 2001. J Med Chem. 44: 4509-23. PMID: 11741471
- Stabilization of guanine quadruplex DNA by the binding of porphyrins with cationic side arms. | Yamashita, T., et al. 2005. Bioorg Med Chem. 13: 2423-30. PMID: 15755644
- Studies on the site and mode of TMPyP4 interactions with Bcl-2 promoter sequence G-Quadruplexes. | Nagesh, N., et al. 2010. Biophys J. 98: 2628-33. PMID: 20513407
- Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. | Fujimori, J., et al. 2011. J Orthop Res. 29: 1707-11. PMID: 21590716
- The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells. | Morris, MJ., et al. 2012. Nucleic Acids Res. 40: 4137-45. PMID: 22266651
- Pentose phosphate pathway function affects tolerance to the G-quadruplex binder TMPyP4. | Andrew, EJ., et al. 2013. PLoS One. 8: e66242. PMID: 23776642
- TMPyP4-regulated cell proliferation and apoptosis through the Wnt/β-catenin signaling pathway in SW480 cells. | Zhang, YQ., et al. 2016. J Recept Signal Transduct Res. 36: 167-72. PMID: 26382555
- TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses. | Zheng, XH., et al. 2016. Sci Rep. 6: 26592. PMID: 27221067
- Telomerase Inhibitor TMPyP4 Alters Adhesion and Migration of Breast-Cancer Cells MCF7 and MDA-MB-231. | Konieczna, N., et al. 2019. Int J Mol Sci. 20: PMID: 31151281
- Three-Dimensional Structure of RNA Monomeric G-Quadruplex Containing ALS and FTD Related G4C2 Repeat and Its Binding with TMPyP4 Probed by Homology Modeling based on Experimental Constraints and Molecular Dynamics Simulations. | Mulholland, K., et al. 2020. ACS Chem Neurosci. 11: 57-75. PMID: 31800202
- The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex. | Chen, J., et al. 2021. Cell Prolif. 54: e13101. PMID: 34296479
- The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene. | Mori, K., et al. 2021. J Biol Chem. 297: 101120. PMID: 34450161
- Cationic Porphyrin-Mediated G-Quadruplex DNA Oxidative Damage: Regulated by the Initial Interplay between DNA and TMPyP4. | Zhou, W., et al. 2021. Biochemistry. 60: 3707-3713. PMID: 34757721
- Porphyrin binding to quadrupled T4G4. | Anantha, NV., et al. 1998. Biochemistry. 37: 2709-14. PMID: 9537740
- Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. | Izbicka, E., et al. 1999. Cancer Res. 59: 639-44. PMID: 9973212
Inhibitor of:
TERT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMPyP4, 25 mg | sc-204346 | 25 mg | $108.00 | |||
TMPyP4, 250 mg | sc-204346A | 250 mg | $159.00 | |||
TMPyP4, 500 mg | sc-204346B | 500 mg | $287.00 |