TERC Activators
TERC activators, also known as Telomerase RNA Component activators, represent a group of compounds that play a pivotal role in cellular biology, specifically in the maintenance and regulation of telomeres. Telomeres are repetitive DNA sequences found at the ends of eukaryotic chromosomes, and they serve as protective caps that safeguard the integrity of genetic information during cell division. TERC, or Telomerase RNA Component, is an essential part of the telomerase enzyme complex, which is responsible for elongating telomeres. TERC activators, as the name implies, are molecules or substances that stimulate the activity of TERC in cells, ultimately influencing telomere length and cellular aging processes.
At the molecular level, TERC activators are thought to function by binding to the TERC RNA molecule, facilitating its proper folding and assembly into the telomerase complex. This enhancement in TERC stability and functionality promotes telomerase's ability to elongate telomeres, preventing them from shortening with each cell division. As telomeres shorten over time due to natural replication, cellular stress, or various environmental factors, cells may eventually reach a state of replicative senescence or apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1, leading to increased TERC expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways, including NF-κB. | ||||||
Astragaloside IV | 84687-43-4 | sc-257103 | 20 mg | $57.00 | 1 | |
Promotes TERC expression through the PI3K/Akt pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
May upregulate TERC by inhibiting DNA methyltransferases. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Boosts NAD+ levels, which can enhance TERC transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Also inhibits HDACs, leading to TERC upregulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
May induce TERC expression via Nrf2 activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that can increase TERC transcription. | ||||||