TERC Inhibitors
TERC inhibitors belong to a specialized class of chemical compounds designed to target the TERC (Telomerase RNA Component) molecule. TERC is a non-coding RNA component of the telomerase enzyme complex, which plays a pivotal role in maintaining the integrity of chromosomal ends, known as telomeres. Telomeres consist of repetitive DNA sequences and associated proteins that protect the ends of chromosomes from degradation and maintain genomic stability during cell division. Over time, telomeres naturally shorten with each cell division, which can eventually lead to cellular senescence or apoptosis. Telomerase, which includes TERC, counteracts this shortening process by adding repetitive DNA sequences to telomeres, thereby extending their length and allowing cells to divide more times.
Inhibitors targeting TERC are designed to interact with this non-coding RNA molecule and disrupt its association with the telomerase enzyme complex or affect its function in telomere elongation. These inhibitors may operate through various mechanisms, such as binding to specific regions of TERC or altering its secondary structure. By inhibiting TERC, these compounds can interfere with telomerase activity, impacting the maintenance of telomere length and influencing cellular lifespan and replicative capacity. Research on TERC inhibitors is primarily focused on elucidating the molecular mechanisms by which TERC contributes to telomere maintenance and exploring strategies to modulate telomerase function, providing insights into cellular aging and genomic stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
A compound that intercalates into DNA and prevents the transcription of RNA, possibly including TERC. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that regulates gene expression by activating nuclear receptors, potentially influencing TERC expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II, which could affect TERC transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that can be incorporated into RNA and DNA, potentially disrupting TERC RNA synthesis and function. | ||||||
BIBR 1532 | 321674-73-1 | sc-203843 sc-203843A | 10 mg 50 mg | $189.00 $733.00 | 6 | |
A small molecule that has been shown to specifically inhibit telomerase activity, which could indirectly reduce TERC levels. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
A small molecule that binds to RNA polymerase I, potentially hindering rRNA synthesis and indirectly affecting TERC. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $240.00 | ||
An inhibitor of RNA polymerase I which could decrease rRNA synthesis and could impact TERC expression indirectly. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
An adenosine analog that disrupts RNA synthesis, which could result in decreased expression of the TERC component. | ||||||
β-Pyrazofurin Trifluoroacetic Acid Salt | 30868-30-5 (free base) | sc-476809 | 1 mg | $480.00 | ||
A nucleoside analog that can inhibit orotidine 5'-phosphate decarboxylase, potentially affecting RNA synthesis and TERC levels. | ||||||