Astragaloside IV (CAS 84687-43-4)
See product citations (1)
QUICK LINKS
Astragaloside IV is a compound that functions as an anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines and mediators. It also acts as an antioxidant, scavenging free radicals and reducing oxidative stress in cells. At the molecular level, Astragaloside IV modulates the expression of genes involved in the inflammatory response and oxidative stress pathways. It may enhance the activity of certain enzymes involved in cellular antioxidant defense mechanisms. Astragaloside IV also plays a role in promoting cell proliferation and inhibiting apoptosis, contributing to its potential protective effects on cells and tissues. Its mode of action involves interacting with specific cellular signaling pathways, ultimately influencing cellular responses to inflammation and oxidative stress. Astragaloside IV demonstrates potential as a research tool for studying the molecular mechanisms underlying inflammation, oxidative stress, and cellular protection.
Astragaloside IV (CAS 84687-43-4) References
- Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. | Zhang, WJ., et al. 2003. Thromb Haemost. 90: 904-14. PMID: 14597987
- Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. | Qian, W., et al. 2018. J Cell Mol Med. 22: 4354-4365. PMID: 29971947
- Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling. | Xu, F., et al. 2018. J Exp Clin Cancer Res. 37: 207. PMID: 30157903
- Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway. | Cheng, S., et al. 2019. Life Sci. 227: 82-93. PMID: 31004658
- Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway. | Wei, Y., et al. 2020. J Ethnopharmacol. 249: 112404. PMID: 31739105
- Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling. | Wang, N., et al. 2020. Biomed Pharmacother. 123: 109729. PMID: 31887543
- Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease. | Xia, ML., et al. 2020. J Neuroinflammation. 17: 105. PMID: 32252767
- Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy. | Wang, E., et al. 2020. Pharmacol Res. 157: 104831. PMID: 32339782
- Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. | Luo, LF., et al. 2021. Mol Cell Biochem. 476: 2603-2611. PMID: 33656642
- Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis. | Wang, F., et al. 2021. Int J Biol Sci. 17: 1821-1836. PMID: 33994865
- Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF-κB signaling pathway. | Shi, H., et al. 2021. J Food Biochem. 45: e13757. PMID: 34032295
- Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling. | Tian, L., et al. 2021. Front Immunol. 12: 740565. PMID: 34589089
- Astragaloside IV pre-treatment attenuates PM2.5-induced lung injury in rats: Impact on autophagy, apoptosis and inflammation. | Wang, Z., et al. 2022. Phytomedicine. 96: 153912. PMID: 35026504
- Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2. | Tang, X., et al. 2022. Bioengineered. 13: 8240-8254. PMID: 35302431
- Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway. | Liu, Z., et al. 2022. Front Pharmacol. 13: 924826. PMID: 36059982
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Astragaloside IV, 20 mg | sc-257103 | 20 mg | $57.00 |