Tenascin-R Inhibitors
Tenascin-R inhibitors represent a novel class of compounds designed to modulate cellular interactions mediated by tenascin-R, a glycoprotein belonging to the tenascin family. Tenascin-R is primarily expressed in the central nervous system, where it plays a pivotal role in regulating cell adhesion, migration, and neurite outgrowth. This glycoprotein is particularly abundant in developing neural tissues and is involved in the guidance of axonal growth during embryogenesis.
The molecular structure of tenascin-R includes multiple distinct domains, such as epidermal growth factor (EGF)-like repeats and fibronectin type III (FNIII) repeats. These domains contribute to the multifaceted functions of tenascin-R, participating in intricate signaling cascades that influence cellular behavior.Inhibitors targeting tenascin-R function by selectively interfering with the protein's binding sites or disrupting the interactions with its molecular partners. This targeted approach aims to modulate the intricate cellular processes regulated by tenascin-R, potentially influencing neural development and plasticity. As researchers delve into the complexities of the interactions between tenascin-R and its associated molecules, the design and development of inhibitors become increasingly sophisticated.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline can inhibit matrix metalloproteinases (MMPs) that are involved in extracellular matrix remodeling, a process that Tenascin-R takes part in. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline is another tetracycline antibiotic that can inhibit MMPs, thus it can indirectly affect Tenascin-R functionality. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is a broad-spectrum MMP inhibitor, thus it can affect the extracellular matrix remodeling and indirectly influence Tenascin-R. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is another broad-spectrum MMP inhibitor that can provide indirect influence on Tenascin-R activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MAPK inhibitor. As MAPK signaling can be involved in the regulation of Tenascin-R, this compound can exert indirect inhibitory effects. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. p38 MAPK is involved in various cellular processes, potentially including those related to Tenascin-R. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. JNK signaling might also be involved in Tenascin-R regulation, thus this compound can provide indirect inhibitory effects. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor. ROCK signaling is involved in cell adhesion and migration, processes that Tenascin-R can influence. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil is another ROCK inhibitor that can indirectly influence Tenascin-R by affecting cell adhesion and migration. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor. PI3K signaling can be involved in the regulation of Tenascin-R, thus this compound can exert indirect inhibitory effects. | ||||||