Tenascin-R Antibody (A-2): sc-376341

Tenascin-R Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tenascin-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Tenascin-R antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Tenascin-R, a member of the Tenascin family of extracellular matrix proteins, plays a crucial role in the central nervous system by influencing neurite outgrowth and neural cell adhesion, which are vital for proper neuronal development and repair. Tenascin-R is predominantly expressed on the surface of neurons and glial cells, where Tenascin-R contributes to the formation of the extracellular matrix, facilitating cell signaling and interaction during critical processes such as morphogenesis and tissue remodeling. The unique structure of Tenascin-R, characterized by a hexameric disulfide-linked configuration, allows Tenascin-R to interact with various cell surface receptors and other extracellular matrix components, thereby modulating cellular behavior and influencing the microenvironment in both healthy and pathological conditions. Understanding Tenascin-R function and interactions is essential for elucidating Tenascin-R′s role in neurodevelopmental disorders and potential therapeutic applications.

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Tenascin-R Antibody (A-2) References:

1. Differential expression of tenascin-C, tenascin-R, tenascin/J1, and tenascin-X in spinal cord scar tissue and in the olfactory system.  |  Deckner, M., et al. 2000. Exp Neurol. 166: 350-62. PMID: 11085900
2. Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins.  |  Lundell, A., et al. 2004. Structure. 12: 1495-506. PMID: 15296743
3. Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function.  |  Liao, H., et al. 2005. J Biol Chem. 280: 8316-23. PMID: 15615725
4. Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan.  |  Morawski, M., et al. 2014. Philos Trans R Soc Lond B Biol Sci. 369: 20140046. PMID: 25225104
5. Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.  |  Mueller-Buehl, C., et al. 2022. Front Cell Dev Biol. 10: 886527. PMID: 35721494
6. The perplexing multifunctionality of janusin, a tenascin-related molecule.  |  Schachner, M., et al. 1994. Perspect Dev Neurobiol. 2: 33-41. PMID: 7530142
7. Tenascins, a growing family of extracellular matrix proteins.  |  Chiquet-Ehrismann, R. 1995. Experientia. 51: 853-62. PMID: 7556567
8. Astrocytes and neurons regulate the expression of the neural recognition molecule janusin by cultured oligodendrocytes.  |  Jung, M., et al. 1993. Glia. 9: 163-75. PMID: 8294147
9. The human tenascin-R gene.  |  Leprini, A., et al. 1996. J Biol Chem. 271: 31251-4. PMID: 8940128
10. Characterization of the bovine tenascin-X.  |  Elefteriou, F., et al. 1997. J Biol Chem. 272: 22866-74. PMID: 9278449
11. The tenascin gene family in axon growth and guidance.  |  Faissner, A. 1997. Cell Tissue Res. 290: 331-41. PMID: 9321695
12. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R.  |  Srinivasan, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 15753-7. PMID: 9861042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tenascin-R Antibody (A-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Tenascin-R Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tenascin-R Antibody (A-2) Specifications

Alternate Product Name: Tenascin R (TNR)

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-60

Epitope Target: Tenascin-R

Epitope Species: human

Product Reactivity/Detection: Tenascin-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Tenascin-R Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin