Tenascin Activators
Tenascin Activators encompass a selection of chemical compounds that indirectly promote Tenascin's activity by influencing various signaling pathways and cellular processes associated with the extracellular matrix (ECM). Forskolin, for instance, increases intracellular cAMP levels, subsequently activating protein kinase A (PKA), which can phosphorylate proteins involved in ECM remodeling, a process where Tenascin is a critical player. Similarly, Epigallocatechin gallate and Genistein, through their kinase inhibition, might shift the signaling equilibrium in such a way as to support Tenascin's role in ECM organization. Sphingosine-1-phosphate and Thapsigargin, by modulating lipid signaling and increasing intracellular calcium, respectively, can potentiate the cellular processes in which Tenascin is fundamentally involved, such as cell adhesion and migration. Moreover, PI3K inhibitors like LY294002 and Wortmannin could indirectly enhance Tenascin activity by impacting cellular survival pathways, potentially leading to ECM component upregulation.
The influence of Tenascin activators extends further through compounds that alter MAPK signaling. PD 98059, a MEK inhibitor, SB203580, a p38 MAPK inhibitor, and U0126, another MEK1/2 inhibitor, could all create conditions that favor Tenascin's contribution to ECM structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates various substrates that can lead to the remodeling of the extracellular matrix (ECM) where Tenascin is involved, thereby potentially enhancing its functional role in ECM organization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate is an inhibitor of various kinases. By modifying kinase activity, this compound can influence signaling pathways that regulate ECM components, potentially leading to an increase in Tenascin activity within the ECM. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that can activate signaling pathways involving cytoskeletal rearrangement and cell adhesion, processes in which Tenascin plays a critical role. Its activation could therefore enhance Tenascin's function in the ECM. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, which can activate downstream signaling pathways critical for cell adhesion and motility, thereby indirectly increasing Tenascin's activity in the ECM. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter cell survival and growth pathways, potentially shifting the balance towards pathways that upregulate ECM components including Tenascin. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that could, by altering cell survival signaling, lead to changes in ECM composition and enhance Tenascin activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor that can affect the MAPK/ERK pathway. This alteration in signaling dynamics could lead to a cellular environment that favors Tenascin's role in the ECM. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting this pathway, the compound could shift signaling towards ECM organization, potentially enhancing Tenascin's role in this process. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK1/2 inhibitor that can modify cell signaling related to growth and differentiation, possibly resulting in increased Tenascin activity within the ECM. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, thus activating pathways that can lead to modifications in cell adhesion mechanisms, indirectly enhancing Tenascin's function. | ||||||