Tenascin-C Antibody (E-9): sc-25328

Tenascin-C Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tenascin-C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Tenascin-C antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tenascin-C, a member of the tenascin family of extracellular matrix proteins, plays a crucial role in cellular adhesion and migration, which are vital processes during development and tissue repair. Tenascin-C is primarily located in the extracellular matrix, where Tenascin-C influences cell behavior by interacting with integrins and other cell surface receptors, thereby modulating cellular responses to environmental cues. Tenascin-C expression is particularly important in tissues undergoing remodeling, such as during wound healing and tumor progression, as Tenascin-C helps regulate the balance between cell adhesion and migration. Tenascin-C′s structure, characterized by multiple EGF-like and fibronectin type-III domains, allows for formation of large hexameric complexes that create a scaffold for cell attachment and migration, further emphasizing Tenascin-C′s significance in developmental processes and tissue homeostasis.

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Tenascin-C Antibody (E-9) References:

1. Tenascin-C in the matrisome of neural stem and progenitor cells.  |  Faissner, A., et al. 2017. Mol Cell Neurosci. 81: 22-31. PMID: 27836730
2. Tenascin-C in Heart Diseases-The Role of Inflammation.  |  Imanaka-Yoshida, K. 2021. Int J Mol Sci. 22: PMID: 34072423
3. Tenascin-C induction exacerbates post-stroke brain damage.  |  Chelluboina, B., et al. 2022. J Cereb Blood Flow Metab. 42: 253-263. PMID: 34689646
4. Tenascin-C as a potential marker for immunohistopathology of doxorubicin-induced cardiomyopathy.  |  Nishikawa, T., et al. 2023. Eur Heart J Open. 3: oead104. PMID: 37908440
5. Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.  |  Nguyen, MB., et al. 2024. Sci Adv. 10: eadi5791. PMID: 38241368
6. Tenascin-C modulates alveolarization in bronchopulmonary dysplasia.  |  Liu, W., et al. 2024. Inflamm Regen. 44: 16. PMID: 38539268
7. The perplexing multifunctionality of janusin, a tenascin-related molecule.  |  Schachner, M., et al. 1994. Perspect Dev Neurobiol. 2: 33-41. PMID: 7530142
8. Tenascins, a growing family of extracellular matrix proteins.  |  Chiquet-Ehrismann, R. 1995. Experientia. 51: 853-62. PMID: 7556567
9. Astrocytes and neurons regulate the expression of the neural recognition molecule janusin by cultured oligodendrocytes.  |  Jung, M., et al. 1993. Glia. 9: 163-75. PMID: 8294147
10. Characterization of the bovine tenascin-X.  |  Elefteriou, F., et al. 1997. J Biol Chem. 272: 22866-74. PMID: 9278449
11. The tenascin gene family in axon growth and guidance.  |  Faissner, A. 1997. Cell Tissue Res. 290: 331-41. PMID: 9321695
12. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R.  |  Srinivasan, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 15753-7. PMID: 9861042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tenascin-C Antibody (E-9) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-Tenascin-C Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tenascin-C Antibody (E-9) Specifications

Alternate Product Name: Tenascin C (TNC)

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1601-1900

Epitope Target: Tenascin-C

Epitope Species: human

Product Reactivity/Detection: Tenascin-C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for Tenascin-C Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin