TECPR2 Inhibitors
TECPR2 inhibitors encompass a variety of chemicals that target the autophagic pathways, where TECPR2 plays a crucial role. These inhibitors act at different stages of autophagy, starting with the initiation phase, where specific chemicals disrupt the formation of the autophagosome by inhibiting enzymes essential for this process. Others prevent the maturation of autophagosomes by halting the fusion with lysosomes or by impeding the acidification that is necessary for the degradation of autophagic contents. This cascade of inhibitory effects compromises the ability of TECPR2 to facilitate the autophagic flux, a critical cellular process for the turnover of cytoplasmic components. By hampering the formation, maturation, and degradation stages of autophagy, these chemical inhibitors collectively diminish the functional activity of TECPR2, offsetting its role in promoting and regulating autophagy.
The inhibition of TECPR2 is also achieved through the indirect action of chemicals that target upstream regulators of autophagy. For instance, chemicals that bind to and inhibit kinases which trigger autophagic mechanisms can lead to a downstream reduction in TECPR2 activity. Additionally, the inhibition of molecular complexes that signal the onset of autophagy also leads to decreased TECPR2 function, as these complexes are integral to the autophagic pathways that TECPR2 supports.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to FKBP12 and inhibits mTOR, which is involved in autophagy. TECPR2 promotes autophagy, thus rapamycin inhibits TECPR2 function by downregulating autophagy. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that prevents the initiation of autophagy. As TECPR2 supports autophagic processes, inhibition of PI3K decreases TECPR2 mediated autophagy. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
Inhibits autophagy by blocking autophagosome formation. TECPR2 function is compromised as it cannot support autophagosome formation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Prevents autophagosome-lysosome fusion and subsequent autophagy degradation, indirectly inhibiting TECPR2's autophagy-promoting role. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Promotes the degradation of Vps34 PI3 kinase complexes, essential for autophagy initiation, therefore reducing TECPR2 related autophagic activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, disrupts autophagy at the initiation stage, limiting TECPR2's function in autophagy. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibits V-ATPase, preventing the acidification of lysosomes, which is essential for autophagosome degradation, thus indirectly inhibiting TECPR2's function in autophagy. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Inhibits V-ATPase and lysosomal acidification, affecting TECPR2's role in autophagic degradation. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $113.00 $1035.00 | 7 | |
Src family kinase inhibitor, impairs the autophagic process by inhibiting necessary signaling pathways, indirectly affecting TECPR2's autophagy-related functions. | ||||||
SBI-0206965 | 1884220-36-3 | sc-507431 | 10 mg | $122.00 | ||
Inhibits ULK1 kinase activity, which is required for the initiation of autophagy, thereby impacting TECPR2's regulatory role in autophagy. | ||||||