TDRD9 Activators
Certain small molecules can indirectly enhance the functional activity of TDRD9, a protein implicated in RNA metabolism and the piRNA pathway, which are vital for transposon silencing and genomic stability, particularly in germ cells. For example, compounds that elevate intracellular cAMP levels can activate protein kinase A. Once activated, this kinase may phosphorylate TDRD9, thereby enhancing its role in piRNA processing. Similarly, agents that serve as protein kinase C activators may also promote the phosphorylation of TDRD9 or proteins within its associated pathways, further influencing its activity in germ cell development. Additionally, substances that inhibit protein phosphatases could lead to an increase in the overall phosphorylation state, potentially boosting the activity of TDRD9 in its gene silencing functions. Furthermore, chromatin-modifying agents, such as inhibitors of DNA methyltransferases or histone deacetylases, can alter the epigenetic landscape, potentially facilitating TDRD9's access to DNA and enhancing its function in piRNA processing and transposon control.
Moreover, the availability of methyl donor molecules is crucial for TDRD9's methylation-related activities, which are essential for the silencing of transposable elements and maintaining genomic integrity. By providing the necessary substrates for methylation reactions, such compounds can bolster the role of TDRD9 in these processes. Additionally, molecules that impact gene expression through certain signaling receptors can modify the activity profile of TDRD9 by altering the gene expression patterns that influence its function. Metal ions that act as cofactors for DNA-binding proteins can stabilize TDRD9's interactions with piRNA complexes, thus supporting its role in transposon silencing. Lastly, compounds that induce DNA hypomethylation can lead to changes in the genomic methylation pattern, which might potentiate the epigenetic silencing capabilities of TDRD9, emphasizing its critical role in the safeguarding of genomic integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
This compound is a potent activator of protein kinase C (PKC), which may phosphorylate TDRD9 or associated proteins. This phosphorylation can modulate the piRNA pathway where TDRD9 is known to play a role in germ cell development. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
As an inhibitor of protein phosphatases PP1 and PP2A, Okadaic acid indirectly increases phosphorylation levels. This can enhance the phosphorylation state of TDRD9, potentially increasing its activity in RNA silencing processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit DNA methyltransferases, modifying the epigenetic landscape. TDRD9, which is involved in gene silencing and transposon control, may have enhanced activity due to altered chromatin states that facilitate its access to DNA. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a methyl donor, it is essential for methylation reactions. TDRD9 may utilize this compound to carry out its function in the methylation of transposons, enhancing gene silencing and maintaining genomic integrity in germ cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
By inhibiting phosphodiesterases, Caffeine increases cAMP levels, which can activate PKA. PKA-mediated phosphorylation could enhance the function of TDRD9 in piRNA processing or modification of associated proteins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It can modulate gene expression through retinoic acid receptors. TDRD9, which has a role in germ cell development, may be affected by the altered gene expression profile induced by Retinoic acid, thereby enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
This cAMP analog directly activates PKA. PKA then could phosphorylate TDRD9, which might result in the increased activity of TDRD9 in piRNA pathway regulation and transposon silencing. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A alters the chromatin structure. This relaxed chromatin could facilitate TDRD9's access to DNA and enhance its function in piRNA-processing and maintaining genomic stability. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This short-chain fatty acid is also an HDAC inhibitor, potentially increasing histone acetylation and altering chromatin structure. This may enhance TDRD9's role in piRNA metabolism and transposon silencing by facilitating DNA access. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many DNA-binding proteins. By stabilizing protein-DNA interactions, Zinc sulfate could enhance TDRD9's function with piRNA complexes, which is essential for transposon silencing and genome integrity. | ||||||