TCR C β Activators
The T cell receptor C beta (TCR C β) forms an integral part of the immune response machinery, serving as a critical component of the T cell receptor complex. This protein typically resides on the surface of T cells, a type of white blood cell that plays a pivotal role in immune responses. TCR C β, along with the alpha chain, forms the antigen-binding site of the T cell receptor complex, enabling it to recognize and bind to antigens presented by major histocompatibility complex (MHC) molecules. This antigen binding triggers the activation of T cells, initiating a cascade of immune responses aimed at combating invading pathogens. The expression of TCR C β is thus crucial in maintaining a robust and responsive immune system.
Several chemical compounds have been identified that could induce the expression of TCR C β. These compounds, often plant-derived molecules, may act by triggering cellular pathways that lead to the transcription and translation of the TCR C β gene. For example, curcumin, a compound found in turmeric, might stimulate the NF-kB pathway, a critical regulator of immune cell differentiation, leading to an increase in TCR C β expression. Similarly, resveratrol, a compound found in grapes and berries, is known to activate Sirtuin 1, which may enhance the transcription of TCR C β, thereby upregulating its expression. Other compounds like quercetin, sulforaphane, and epigallocatechin gallate (EGCG) have also been suggested to stimulate T cell differentiation or activation, which could result in increased TCR C β expression. However, it's important to note that while these compounds could induce TCR C β expression, further research is needed to validate these effects and understand their mechanisms of action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may stimulate the transcription factor NF-kB pathway, which plays an essential role in the transcription of genes related to immune cell differentiation, potentially leading to an increase in TCR C β expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate Sirtuin 1, a protein that controls the transcription of various genes. This activation may enhance the transcription of TCR C β, thereby increasing its expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been observed to stimulate the differentiation of T cells and the subsequent transcription of T cell-specific proteins, which could lead to an upregulation of TCR C β. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane can activate the Nrf2 pathway, a key player in the cellular response to oxidative stress. This activation may induce the transcription and expression of various proteins, including TCR C β. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could potentially stimulate the differentiation of T cells, which may result in the increased transcription and subsequent expression of TCR C β. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is known to stimulate signaling pathways in immune cells, which may lead to an enhanced transcription of immune-specific genes, such as TCR C β, thereby increasing its expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, as an activator of adenylate cyclase, could potentially enhance cAMP levels, which may trigger the transcription of various genes, including TCR C β, leading to its increased expression. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Daidzein has been observed to stimulate signaling pathways in immune cells. This stimulation may lead to an enhanced transcription of immune-specific genes, resulting in increased expression of TCR C β. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol may stimulate the differentiation of T cells, which could lead to an increase in the transcription and subsequent expression of TCR C β. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is known to stimulate the differentiation of T cells, which may lead to an upregulation of TCR C β transcription and expression. | ||||||