TBRG1 Inhibitors
TBRG1 inhibitors encompass compounds that can indirectly suppress the functional activity of TBRG1 by interacting with various signaling pathways. TBRG1, also known as transforming growth factor beta regulator 1, does not have well-characterized direct chemical inhibitors, but there are several pathways through which its activity can be influenced. Inhibitors of the PI3K/AKT pathway, such as LY294002 and Wortmannin, can decrease the phosphorylation of downstream proteins, thereby potentially reducing the phosphorylation state of TBRG1 and its subsequent activity.
In addition,TBRG1 inhibitors encompass compounds that can indirectly suppress the functional activity of TBRG1 by interacting with various signaling pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3Ks). It can lead to the inhibition of AKT signaling, which is necessary for the phosphorylation of many proteins, including TBRG1. By inhibiting PI3K, LY294002 can decrease AKT activity and thus reduce the phosphorylation and functional activity of TBRG1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2). MEK1/2 is part of the MAPK/ERK pathway, which can regulate the activity of a variety of proteins, including TBRG1. By inhibiting MEK1/2, U0126 can prevent the phosphorylation of ERK1/2 kinases, potentially diminishing the downstream phosphorylation of TBRG1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK. The p38 MAPK pathway is involved in the stress response and can modulate the activity of various substrates, including TBRG1. SB203580 prevents the activation of p38 MAPK, possibly leading to reduced stress-induced phosphorylation of TBRG1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK). JNK is involved in the cellular stress response and can influence the activity of numerous proteins. Inhibition by SP600125 could decrease JNK-mediated phosphorylation events that might otherwise modulate TBRG1 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent and irreversible inhibitor of PI3K. Similar to LY294002, Wortmannin’s inhibition of PI3K can lead to decreased activity of AKT and subsequent downregulation of phosphorylation on proteins like TBRG1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A specific inhibitor of the mammalian target of rapamycin (mTOR). mTOR is part of two complexes, mTORC1 and mTORC2, which are involved in the regulation of cell growth and survival. Rapamycin inhibits mTORC1, which could indirectly affect the phosphorylation status and activity of TBRG1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK1, which, like U0126, can prevent the activation of the MAPK/ERK pathway. This inhibition would impede the downstream phosphorylation of ERK1/2 and potentially reduce the phosphorylation-dependent activity of TBRG1. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a wide range of substrates, altering their activity. Inhibition by PP2 could reduce Src kinase-mediated phosphorylation of TBRG1, leading to its functional inhibition. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
An inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. EGFR signaling can result in the activation of various downstream pathways, including those that might phosphorylate TBRG1. Inhibition by Gefitinib could thus reduce EGFR-mediated functional activation of TBRG1. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Similar to Gefitinib, Erlotinib selectively inhibits EGFR tyrosine kinase. By blocking EGFR signaling, Erlotinib can decrease the activation of downstream kinases that may influence TBRG1 phosphorylation and activity. | ||||||