TaR-1 Inhibitors
TaR-1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the trace amine-associated receptor 1 (TaR-1), a member of the G-protein-coupled receptor (GPCR) family. TaR-1 is widely expressed in various tissues, including the central nervous system, and is activated by trace amines, which are biogenic amines present in low concentrations in the body. These trace amines, such as β-phenylethylamine, octopamine, and tyramine, function as signaling molecules that modulate various physiological processes. TaR-1 plays a key role in regulating intracellular signaling pathways, including those associated with neurotransmitter systems. By inhibiting TaR-1, these compounds block its ability to respond to trace amines, leading to altered intracellular signaling dynamics and potential changes in the regulation of neurotransmission, metabolic processes, and cell signaling.
Research into TaR-1 inhibitors is crucial for understanding the broader role of trace amine receptors in cellular communication and the modulation of physiological functions. By inhibiting TaR-1, scientists can explore how this receptor influences the activity of neurotransmitter systems, particularly those involving dopamine, serotonin, and norepinephrine, which interact with trace amines in complex ways. TaR-1 inhibitors allow researchers to investigate the receptor's role in fine-tuning the sensitivity of these neurotransmitter systems to trace amines, providing insights into its impact on mood regulation, cognitive processes, and metabolic pathways. Additionally, these inhibitors serve as useful tools for studying the signaling mechanisms that are triggered by trace amines and how TaR-1 functions in different tissues, offering a deeper understanding of the physiological importance of trace amines and their receptors in maintaining cellular homeostasis and communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin directly inhibits mitochondrial ATP synthase, which could lead to decreased ATP production, potentially causing a downregulation of TAR1 expression due to altered mitochondrial energetics. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A binds and inhibits complex III of the mitochondrial electron transport chain, leading to a blockade of electron flow which can result in reduced mRNA synthesis and consequent downregulation of TAR1 expression. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol selectively binds to mitochondrial ribosomes based on their bacterial origin, inhibiting protein synthesis. This inhibition can cause a decrease in TAR1 protein production due to disrupted mitochondrial translation processes. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide obstructs the translocation step in eukaryotic protein synthesis, which could lead to a decrease in overall protein production, including the synthesis of TAR1. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Actinonin is a competitive inhibitor of peptide deformylase, an enzyme involved in the N-terminal methionine processing of nascent proteins, which could result in the decreased synthesis of TAR1 in mitochondria. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline hinders the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site, potentially leading to a decrease in mitochondrial protein synthesis, which may include TAR1. | ||||||
Roxithromycin | 80214-83-1 | sc-205845 sc-205845A | 1 g 5 g | $51.00 $153.00 | ||
Roxithromycin, by binding to mitochondrial ribosomes, can lead to an inhibition of protein synthesis within the mitochondria, potentially resulting in decreased levels of TAR1. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Ethidium bromide intercalates with mitochondrial DNA, which can lead to the cessation of transcription and replication of mitochondrial DNA, potentially leading to a decrease in TAR1 expression. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $149.00 | 7 | |
Paraquat induces the formation of superoxide radicals within mitochondria, which can cause oxidative damage to mitochondrial components, potentially leading to decreased expression of TAR1 due to a general stress response. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of complex I in the mitochondrial electron transport chain, leading to reduced electron transport and potential downregulation of TAR1 as a secondary effect of energy deprivation. | ||||||