Molecular structure of Actinonin, CAS Number: 13434-13-4
Actinonin (CAS 13434-13-4)
See product citations (3)
Alternate Names:
3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
Application:
Actinonin is an antibiotic shown to inhibit CD13, MMP-1,2,3,7,8,9,10,12, and MMP-13
CAS Number:
13434-13-4
Purity:
≥95%
Molecular Weight:
385.50
Molecular Formula:
C19H35N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of CD13 and Aminopeptidase (leucine aminopeptidase). Actinonin has been observed to inhibit PDF (peptide deformylase), meprin A, and thermolysin. This compound inhibits matrix metalloproteinases (MMP) such as MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12, and MMP-13, but not MMP-14. Actinonin also inhibits tumor cell invasion and matrix degradation along with antitumor and apoptosis inducing activity in vitro.
Actinonin (CAS 13434-13-4) References
- Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. | Chen, DZ., et al. 2000. Biochemistry. 39: 1256-62. PMID: 10684604
- Actinonin induces apoptosis in U937 leukemia cells. | Grujic, M., et al. 2005. Cancer Lett. 223: 211-8. PMID: 15896455
- Identifying common metalloprotease inhibitors by protein fold types using Fourier transform mass spectrometry. | Mitchell, JK., et al. 2007. Bioorg Med Chem Lett. 17: 6521-4. PMID: 17933532
- Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. | Bylander, JE., et al. 2007. Biol Chem. 388: 1163-72. PMID: 17976009
- Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. | Takayama, J., et al. 2008. Eur J Pharmacol. 581: 157-63. PMID: 18093581
- Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. | Wang, Z., et al. 2011. Shock. 35: 141-7. PMID: 20577148
- The Inhibition and Resistance Mechanisms of Actinonin, Isolated from Marine Streptomyces sp. NHF165, against Vibrio anguillarum. | Yang, N. and Sun, C. 2016. Front Microbiol. 7: 1467. PMID: 27679625
- Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. | Umezawa, H., et al. 1985. J Antibiot (Tokyo). 38: 1629-30. PMID: 2867082
- Characterization and evaluation of antimicrobial activity of actinonin against foodborne pathogens. | Jung, D., et al. 2017. Food Sci Biotechnol. 26: 1649-1657. PMID: 30263702
- A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance. | Goodman, CD., et al. 2020. Elife. 9: PMID: 32678064
- Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma. | Ahlawat, P., et al. 2022. Drug Deliv. 29: 2403-2413. PMID: 35892161
- Comparison of native matrix metalloproteinases and their recombinant catalytic domains using a novel radiometric assay. | Brownell, J., et al. 1994. Arch Biochem Biophys. 314: 120-5. PMID: 7944383
- Gene expression, purification and characterization of recombinant human neutrophil collagenase. | Ho, TF., et al. 1994. Gene. 146: 297-301. PMID: 8076835
- Examination of stability of anticonvulsants in a protease solution and assay of anticonvulsants in hairs. | Fujii, J., et al. 1996. Biol Pharm Bull. 19: 1614-7. PMID: 8996650
- Alanyl aminopeptidase from human seminal plasma: purification, characterization, and immunohistochemical localization in the male genital tract. | Huang, K., et al. 1997. J Biochem. 122: 779-87. PMID: 9399582
- Antitumor activity of actinonin in vitro and in vivo. | Xu, Y., et al. 1998. Clin Cancer Res. 4: 171-6. PMID: 9516967
- Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299. | Lendeckel, U., et al. 1998. Biochem Biophys Res Commun. 252: 5-9. PMID: 9813136
Inhibitor of:
1190007I07Rik, ADRM1, Aminopeptidase, Aminopeptidase B, Aminopeptidase B-L1, Aminopeptidase P, Aminopeptidase P1, Aminopeptidase P2, Aminopeptidase P3, aminopeptidase-I, apoOL, ARL8A, BC048546, C14orf21, C3orf60, CCDC44, CD13, CHPPR, CPA4, CPM, Dispase I, Enzyme, ERAL1, ERAP2, FASTKD2, FASTKD3, FLRT3, GABP-β1, GTPBP10, GTPBP3, GTPBP8, H2-Q2, Herc3, HS6ST1, ICT1, IMMP1L, IMMP2L, laeverin_4833403I15Rik, LAP3, Lipocalin-5, LOC100040299, LOC100040585, LONP1, LRP130, Meprin A, Meprin Aβ, MINOS1, Misato, MMP, MMP-1, MMP-10, MMP-12, MMP-13, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MRP-L33, MRP-L46, MRP-L54, MRPL28, mt-TyrRS, MTERFD2, Mtif3, MTRF1L, NAALAD2, NAALADL2, OSAP, Parkin, PCPE-1, PDF, PEPD, pilD, RMND1, RPUSD1, RPUSD2, SerRSmt, SLC43A3, TaR-1, TFB1M, TFB2M, Tim13A/B, TMEM11, Tom20, Tom34, Tom7, Ubr4, UQCRB, VibH, and VPS13C.Activator of:
Aminopeptidase A, APNG, APO, ELYS, ENOPH1, MARCH5, Meprin A, MRP-L37, MRRF, MTERF, p53AIP1, P5CR, and TaR-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Actinonin, 5 mg | sc-201289 | 5 mg | $170.00 | |||
Actinonin, 10 mg | sc-201289B | 10 mg | $385.00 |