TAJ-α Inhibitors
TAJ-α inhibitors are a class of chemical compounds designed to specifically target and block the activity of TAJ-α, a protein involved in various signaling pathways that regulate cellular communication and interaction. TAJ-α, also known as TROY or tumor necrosis factor receptor superfamily member 19, is a member of the TNF receptor superfamily and is known to play a role in modulating cellular functions like apoptosis, cell differentiation, and immune responses. TAJ-α is expressed in various tissues and its signaling pathways are associated with the regulation of key processes such as cell survival, migration, and development. By inhibiting TAJ-α, these compounds interfere with the protein's ability to interact with its downstream signaling partners, providing insights into how TAJ-α influences cellular dynamics and communication.
Inhibitors of TAJ-α are essential tools for exploring the molecular mechanisms through which this receptor influences intracellular signaling cascades. By blocking TAJ-α activity, researchers can investigate the downstream effects on signal transduction pathways, such as those involving NF-kB or MAPK, which are known to control gene expression and cellular responses to environmental stimuli. This inhibition helps to uncover the specific roles TAJ-α plays in regulating cellular behavior, offering insights into how cells respond to stress signals, maintain homeostasis, or undergo structural changes. Additionally, TAJ-α inhibitors allow scientists to study the interactions between TAJ-α and other members of the TNF receptor superfamily, deepening our understanding of how receptor-mediated signaling contributes to broader biological processes such as tissue development and immune regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 could downregulate TAJ-α expression by inhibiting the JNK signaling cascade, which is a key pathway TAJ-α may utilize to mediate its effects on cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
By inhibiting MEK1/2 within the MAPK/ERK pathway, PD 98059 may reduce TAJ-α expression as this pathway can directly control the transcription of numerous genes, potentially including TAJ-α. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 may decrease TAJ-α expression through the blockade of PI3K, leading to a reduction in Akt phosphorylation and subsequent transcriptional activity that could otherwise upregulate TAJ-α. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 could prevent the nuclear translocation of NF-κB by inhibiting IκBα phosphorylation, thereby reducing NF-κB-driven TAJ-α transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By demethylating cytosine bases within the TAJ-α gene promoter, 5-Azacytidine may lead to a reduction in TAJ-α transcription, as DNA methylation status can directly influence gene expression levels. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid may diminish TAJ-α expression by increasing histone acetylation, which can alter chromatin structure and suppress the initiation of transcription at the TAJ-α gene locus. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide could inhibit the transcriptional machinery, leading to a broad decrease in gene expression that includes a reduction in TAJ-α mRNA synthesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate TAJ-α by inhibiting the activation of NF-κB, a transcription factor that could be responsible for initiating TAJ-α transcription. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin may lead to a decrease in TAJ-α expression by inhibiting the activation of STAT3, a transcription factor that, if involved in TAJ-α gene regulation, plays a critical role in its expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol could suppress TAJ-α expression through its ability to inhibit NF-κB, which might be a crucial factor for the transcription of the TAJ-α gene. | ||||||