TAF II p250 Activators
TAF II p250 activators encompass a diverse array of compounds that, through various pathways, result in the upregulation or enhanced activity of TAF II p250, a transcriptional coactivator involved in the initiation of gene transcription by RNA polymerase II. The class includes small molecules that either directly interact with pathways modulating transcription factors or indirectly influence the chromatin structure and the transcriptional machinery.
The activation mechanisms involve the interplay between second messengers such as cAMP, hormonal signaling molecules like thyronine and estradiol, which engage nuclear hormone receptors, and signaling cascades initiated by growth factors such as EGF. The modulation of kinase activity through agents like Forskolin and A-769662 culminates in the phosphorylation and regulation of transcription factors that govern the expression of TAF II p250. Concurrently, epigenetic modifiers such as Trichostatin A and 5-Azacytidine alter the chromatin landscape, making it more permissive for transcription factor binding and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP is a second messenger that activates protein kinase A (PKA). PKA can phosphorylate various transcription factors, which can enhance their ability to promote the expression of TAF II p250. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and modulate transcription factors that increase TAF II p250 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels and activation of PKA. This cascade can stimulate transcription factors that upregulate TAF II p250. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3β, leading to stabilization and nuclear translocation of β-catenin, which can activate transcription factors that increase TAF II p250 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs) which then act as transcription factors to increase gene expression, including potentially the genes involved in the transcription machinery such as TAF II p250. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
T3 hormone binds to thyroid hormone receptors which can regulate transcriptional machinery and potentially upregulate TAF II p250 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol binds estrogen receptors which can act as transcription factors to modulate the expression of a wide range of target genes, including those related to the transcription apparatus such as TAF II p250. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone binds to the glucocorticoid receptor, which may enhance the expression of genes involved in the transcriptional machinery, possibly including TAF II p250. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 activates AMP-activated protein kinase (AMPK), which can influence transcription factors and coactivators involved in the regulation of TAF II p250 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor that can lead to a relaxed chromatin structure, potentially enhancing the accessibility of transcription factors to the promoters of genes including that of TAF II p250. | ||||||