Molecular structure of L-3,3′,5-Triiodothyronine, free acid, CAS Number: 6893-02-3
L-3,3′,5-Triiodothyronine, free acid (CAS 6893-02-3)
Alternate Names:
Triiodothyronine; Tresitope
Application:
L-3,3′,5-Triiodothyronine, free acid is a hormone produced by the thyroid gland
CAS Number:
6893-02-3
Purity:
≥94%
Molecular Weight:
650.97
Molecular Formula:
C15H12I3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-3,3′,5-Triiodothyronine, free acid, also referred to as triiodothyronine (T3), is a vital hormone synthesized by the thyroid gland. This hormone, derived from the amino acid tyrosine. At the cellular level, L-3,3′,5-Triiodothyronine, free acid exerts its influence by targeting the nucleus and modulating gene expression. It achieves this through the binding of thyroid hormone receptors, acting as transcription factors that regulate the activation or inhibition of genes associated with metabolism, growth, and development.
L-3,3′,5-Triiodothyronine, free acid (CAS 6893-02-3) References
- The recovery of 3:5:3' -triiodothyroacetic acid and 3:3' -diiodothyronine from rat kidney after injection of 3:5:3' triiodothyronine. | JOUAN, P., et al. 1956. Endocrinology. 59: 425-32. PMID: 13375558
- Effect of L-3,3'5-triiodothyronine on epinephrine-induced contraction of isolated rabbit aortic strip. | SHEMANO, I. and FALLON, PC. 1960. Proc Soc Exp Biol Med. 103: 282-5. PMID: 14445803
- Effects of gamma-hexachlorocyclohexane and L-3,3',5-triiodothyronine on rat liver cytochrome P4502E1-dependent activity and content in relation to microsomal superoxide radical generation. | Fernández, V., et al. 2003. Biol Res. 36: 359-65. PMID: 14631868
- Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress. | Videla, LA. 2010. IUBMB Life. 62: 460-6. PMID: 20503439
- L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors. | Moffett, SX., et al. 2019. PLoS One. 14: e0223272. PMID: 31584962
- Inhibition of horse liver alcohol dehydrogenase by L-3,3',5-triiodothyronine. | Gilleland, MJ. and Shore, JD. 1969. J Biol Chem. 244: 5357-60. PMID: 4310093
- Cardiac myocyte differentiation induced by 3,5,3'-triiodo-L-thyronine (T3) in P19 teratocarcinoma cells is accompanied by preferential binding of RGG(T/A)CA direct repeats spaced by 4 base pairs in the DNA. | Rodriguez, ER., et al. 1994. Biochem Biophys Res Commun. 205: 1899-906. PMID: 7811280
- Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling. | Williams, GR., et al. 1994. Endocrinology. 135: 2375-85. PMID: 7988420
Inhibitor of:
ALX3, c-Erb-A α, CLK1, FOXB1, GLIS3, GPx-8, Mrf-2, OLIG2, PiT2, SLC7A6, SRp40, TLE6, and Y+LAT1.Activator of:
α-chimaerin, μ-crystallin, 3β-HSD7, 4933421E11Rik, AbdA, ABHD4, ACE, ACOT11, ACSBG1, Akp-5, apoA-I, Arylsulfatase H, ASC2, ATP1B3, B9D1, BM88, brevican, c-Erb-A α, c-Erb-A α-1, c-Erb-A α-2, c-Erb-A β-1, c-Erb-A β-2, C16orf48_E130303B06Rik, C4ST-2, Carnitine Acetyltransferase, CASPR, CASPR2, CES7, CHT1, CLCA2, CNOT2, CNOX, Contactin 6, COQ10A, CPTI-L, CPTI-M, CT45-5, CTL5, CTXL, CYP7A1, DAZL, DEHAL1, Dlx-4, DPP10, EG623286, ELOVL3, Ermin, FAM47E, FAM49B, FGF-17, Flipt1, FOXI2, GCDH, GDE2, GH, Gliomedin, Gm694, GPR172B, HCF2, HCR, HEN2, HESX1, Hexokinase, HMGCR, HoxC10, HoxC11, HRG-β, IFT81, INSL6, INSM2, intestinal cell kinase, KCNA10, KIAA1586, KIR3DL3, KLHDC4, KQT2, KRTAP15-1, KRTAP4-2, KRTAP9-L1, KV2.1, L-Malate Dehydrogenase, L-type Ca++ CP β4, LDLRAD2, Leiomodin 3, LLGL4, LLH3, LOC100039801, LOC100040781, LPAAT-θ, LPGAT1, LRRC6, MafA, MBP-probe, MDFIC, Med7, MFSD9, MOG, MUP, MUP15, MYH1, MYH4, MYH8, Myosin Ih, NAT-1, NCoA-5, NF-H, NKX1-1, NPSF, OATP2A1, Ob, OR10K1, OR6F1, OTTMUSG00000002043, OTTMUSG00000012557, OTTMUSG00000012817, PEPCK-C, Perilipin, Phd, PLAGL1, plexin-A4, PNS Myelin, Pol II RPB6, PRDM16, PRH1, Prop-1, PTPN20, Rab 27a, RBQ-3, Reg Iβ, RFX1, Rhox3c, Sc5d, Sgo1, SLC22A14, SLC25A14, SLC25A20, SLC35F3, Slxl1, sMtCK, SNAT1, SNAT2, SNAT6, SNX7, SOAT1, Sox-13, SULT1A3, SULT1A4, SULT2A2, SUR-2, Syntaxin 10, TAAR6, TAF II p250, TAFA4, TAPP2, TBC1D10C, TBG, TBL1X, TBRG4, TFEC, Thyroperoxidase, Thyroxine, TMEM18, TMEM51, TMEM61, TR α, TRβ1, TRβ2, TRAP230, TRH-R2, Tropomyosin γ, Troponin C slow skeletal, TSHβ, TSHR, TTF-1, UCP1, UGT1A3, UPK1B, USF-1, UT-A, Vgl-4, VGLUT1, Vmn2r121, XTRP3S1, and ZAG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-3,3′,5-Triiodothyronine, free acid, 10 mg | sc-204035 | 10 mg | $40.00 | |||
L-3,3′,5-Triiodothyronine, free acid, 100 mg | sc-204035A | 100 mg | $75.00 | |||
L-3,3′,5-Triiodothyronine, free acid, 250 mg | sc-204035B | 250 mg | $150.00 |