TAF II p140 Activators
The chemical class known as TAF II p140 Activators comprises various compounds that can indirectly influence the activation of TAF II p140, also referred to as TAF3, an essential component of the transcription factor IID (TFIID) complex. TAF3 plays a pivotal role in the initiation of transcription, which is the first step in gene expression, and its activation is crucial for proper transcriptional regulation. One group of compounds within the TAF II p140 Activators class includes histone deacetylase (HDAC) inhibitors like Trichostatin A (TSA) and Valproic Acid. These agents can elevate histone acetylation levels, a key epigenetic modification associated with gene activation. By enhancing histone acetylation, these compounds indirectly promote TAF3's involvement in transcription initiation. Additionally, DNA demethylating agents such as 5-Azacytidine and Decitabine reduce DNA methylation, enabling the upregulation of genes where TAF3 plays a crucial role. These compounds indirectly support TAF3 activation by modifying the epigenetic landscape at gene promoter regions, facilitating the recruitment of the TFIID complex and, consequently, TAF3.
Furthermore, some TAF II p140 Activators, like A23187 and Phorbol 12-myristate 13-acetate (PMA), impact cellular signaling pathways. A23187, a calcium ionophore, can elevate intracellular calcium levels, potentially influencing TAF3's role in transcriptional regulation through calcium-dependent signaling pathways. PMA, on the other hand, can activate protein kinase C (PKC) pathways, which can modulate TAF3's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can activate TAF3 by binding to retinoic acid receptors (RARs) and promoting the expression of genes involved in transcription initiation, indirectly supporting TAF3's function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can indirectly activate TAF3 by increasing histone acetylation, which can enhance gene expression and transcriptional activity involving TAF3. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is another histone deacetylase inhibitor that can promote TAF3 activation by enhancing histone acetylation, thereby facilitating gene transcription processes where TAF3 is involved. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is a solvent for various compounds, and it can indirectly activate TAF3 by serving as a vehicle for other TAF3-activating agents or compounds. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA demethylating agent that indirectly activates TAF3 by reducing DNA methylation, which can lead to the upregulation of genes involved in transcription, including those requiring TAF3. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, an HDAC inhibitor, can indirectly support TAF3 activation by increasing histone acetylation levels, promoting the expression of genes where TAF3 plays a role in transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a demethylating agent that indirectly activates TAF3 by reducing DNA methylation, which can enhance the transcription of genes in which TAF3 participates. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, another histone deacetylase inhibitor, indirectly supports TAF3 activation by increasing histone acetylation, thereby facilitating gene transcription processes involving TAF3. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that indirectly activates TAF3 by elevating intracellular calcium levels, potentially influencing gene expression and transcription processes involving TAF3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can indirectly activate TAF3 by activating protein kinase C (PKC) pathways, which can modulate TAF3's function in transcription initiation. | ||||||