TAF II p130 Inhibitors
Chemical inhibitors of TAF II p130 function through various mechanisms to interfere with the transcriptional processes where TAF II p130 is involved. Triptolide exerts its inhibitory action by targeting signaling pathways that are crucial for transcriptional machinery, thus impairing the formation of transcriptional complexes that require TAF II p130. ICG-001 specifically binds to CBP and disrupts its interaction with β-catenin, a key coactivator interaction necessary for the recruitment of TAF II p130 to the transcriptional complex. Selinexor operates by inhibiting exportin 1, leading to nuclear accumulation of transcription factors and potentially saturating the transcriptional machinery, which would include TAF II p130. Curcumin acts upstream, targeting the NF-κB pathway, which, when inhibited, can diminish the recruitment of TAF II p130 to target genes due to reduced transcription factor activity.
Rocaglamide, by binding to eIF4A, inhibits the initiation of translation of various proteins including transcription factors that would otherwise interact with TAF II p130, hence indirectly reducing its functional role in gene expression. JQ1 targets BRD4, a protein that influences the recruitment of transcriptional machinery to chromatin; its inhibition can decrease the engagement of TAF II p130 in gene transcription. U0126 inhibits MEK1/2, which are part of the MAPK pathway, leading to a downstream decrease in transcription factor activity and consequently less involvement of TAF II p130. C646 prevents the activation of transcription factors by inhibiting p300, a histone acetyltransferase, thus potentially limiting the coactivating role of TAF II p130. SNS-032 targets CDKs involved in the regulation of transcription and its inhibition might impede the phosphorylation of RNA polymerase II, which is crucial for the transcriptional engagement of TAF II p130. Lastly, BI-2536 and SAHA disrupt cell cycle progression and alter chromatin structure, respectively, which can lead to a reduced demand for or aberrant recruitment of TAF II p130 in the transcription initiation process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide targets multiple signaling pathways, including those involved in the transcriptional machinery where TAF II p130 operates. Triptolide can inhibit the activity of transcription factors and, by extension, the function of coactivators such as TAF II p130 by impairing the formation of the transcriptional complex. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
Selinexor functions by inhibiting exportin 1 (XPO1), leading to the accumulation of transcription factors in the nucleus, which can saturate the available TAF II p130 and other transcriptional machinery components, thereby inhibiting their function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit the NF-κB pathway, which plays a role in the transcription of various genes. By inhibiting this pathway, curcumin can attenuate the recruitment of TAF II p130 to the transcriptional complex, inhibiting its function. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation initiation by binding to eIF4A, an essential component of the translation initiation complex. This inhibition leads to a reduction in the synthesis of various proteins, including transcription factors that TAF II p130 would coactivate, thereby indirectly inhibiting TAF II p130 function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits BRD4, a member of the BET family of bromodomain proteins, which are known to regulate gene expression. By inhibiting BRD4, JQ1 can reduce the recruitment of transcriptional machinery, including TAF II p130, to promoters, thus inhibiting its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Inhibition of this pathway can result in decreased activation of transcription factors that recruit TAF II p130 for gene expression, thus functionally inhibiting TAF II p130. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a selective inhibitor of p300, a histone acetyltransferase that acetylates lysine residues on histones and transcription factors. By inhibiting p300, C646 can prevent the acetylation and activation of transcription factors that require TAF II p130, thus inhibiting its function. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a cyclin-dependent kinase (CDK) inhibitor, with specificity towards CDK2, CDK7, and CDK9. CDK7 and CDK9 are integral to transcriptional regulation, and their inhibition by SNS-032 can limit the phosphorylation of RNA polymerase II and other transcriptional activators, thus inhibiting TAF II p130 function. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI-2536 is a Plk1 inhibitor, and Plk1 is involved in cell cycle progression. By inhibiting Plk1, BI-2536 can lead to cell cycle arrest, which would reduce the demand for transcriptional initiation and, consequently, the function of TAF II p130 in the transcriptional process. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase (HDAC) inhibitor, which increases acetylation of histones, leading to a more relaxed chromatin structure. This can lead to aberrant recruitment of transcription complexes and, in some contexts, can inhibit the specific recruitment and function of TAF II p130 in transcription initiation. | ||||||