TAF II p130 Antibody (4A6): sc-736
- TAF II p130 Antibody (4A6) is a mouse monoclonal IgG2a κ TAF II p130 antibody, cited in 17 publications, provided at 200 µg/ml
- TAF II p130 Antibody (4A6) is recommended for detection of TAF II p130 of human origin by WB, IP, IF and IHC(P); non cross-reactive with TAF II p130 of hamster and Drosophila origin
- Anti-TAF II p130 Antibody (4A6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-736 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TAF II p130 Antibody (4A6) for WB and IHC(P) applications. This reagent is now offered in a bundle with TAF II p130 Antibody (4A6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TAF II p130 Antibody (4A6) is a mouse monoclonal IgG2a kappa light chain antibody that detects TAF II p130 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry (IHC). TAF II p130 (4A6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. TAF II p130 functions as a coactivator for NFAT transcriptional activators, which are essential for regulating the expression of cytokines involved in immune responses and inflammation. This function is particularly important as TAF II p130 helps modulate the immune system′s response to various stimuli, ensuring a balanced reaction that is vital for maintaining homeostasis and preventing overactive immune responses that could lead to autoimmune diseases. TAF II p130 participates in the TFIID complex, which is integral to the transcriptional machinery, facilitating the assembly of the preinitiation complex at the TATA promoter element. Understanding TAF II p130′s role in transcriptional regulation and immune response enables researchers to better explore therapeutic targets for diseases related to immune dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAF II p130 Antibody (4A6) References:
- Human Taf(II)130 is a coactivator for NFATp. | Kim, LJ., et al. 2001. Mol Cell Biol. 21: 3503-13. PMID: 11313476
- Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau). | Takada, R., et al. 1992. Proc Natl Acad Sci U S A. 89: 11809-13. PMID: 1465404
- Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. | Dynlacht, BD., et al. 1991. Cell. 66: 563-76. PMID: 1907890
- The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. | Sekiguchi, T., et al. 1991. Mol Cell Biol. 11: 3317-25. PMID: 2038334
- Five intermediate complexes in transcription initiation by RNA polymerase II. | Buratowski, S., et al. 1989. Cell. 56: 549-61. PMID: 2917366
- Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line. | Sekiguchi, T., et al. 1988. EMBO J. 7: 1683-7. PMID: 3169001
- Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. | Matsui, T., et al. 1980. J Biol Chem. 255: 11992-6. PMID: 7440580
- The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1. | Hisatake, K., et al. 1993. Nature. 362: 179-81. PMID: 8450888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAF II p130 Antibody (4A6) | sc-736 | 200 µg/ml | $322.00 | |||
TAF II p130 Antibody (4A6): m-IgGκ BP-HRP Bundle | sc-520421 | 200 µg Ab, 40 µg BP | $361.00 | |||
TAF II p130 Antibody (4A6) X | sc-736 X | 200 µg/0.1 ml | $322.00 | |||
TAF II p130 Antibody (4A6) AC | sc-736 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TAF II p130 Antibody (4A6) HRP | sc-736 HRP | 200 µg/ml | $322.00 | |||
TAF II p130 Antibody (4A6) FITC | sc-736 FITC | 200 µg/ml | $336.00 | |||
TAF II p130 Antibody (4A6) PE | sc-736 PE | 200 µg/ml | $349.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 488 | sc-736 AF488 | 200 µg/ml | $364.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 546 | sc-736 AF546 | 200 µg/ml | $364.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 594 | sc-736 AF594 | 200 µg/ml | $364.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 647 | sc-736 AF647 | 200 µg/ml | $364.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 680 | sc-736 AF680 | 200 µg/ml | $364.00 | |||
TAF II p130 Antibody (4A6) Alexa Fluor® 790 | sc-736 AF790 | 200 µg/ml | $364.00 |