Molecular structure of KPT 330, CAS Number: 1393477-72-9
KPT 330 (CAS 1393477-72-9)
Alternate Names:
Selinexor; (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic Acid 2-(2-Pyrazinyl)hydrazide; (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N′-(pyrazin-2-yl)acrylohydrazide
CAS Number:
1393477-72-9
Molecular Weight:
443.31
Molecular Formula:
C17H11F6N7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KPT 330 is a highly potent and selective inhibitor that specifically targets chromosome region maintenance 1 protein/exportin 1 (CRM1/XPO1). This compound exerts its inhibitory action by directly binding to and obstructing the function of exportin-1 (XPO1), a critical protein involved in the transportation of numerous proteins from the nucleus to the cytoplasm. By impeding XPO1, KPT 330 effectively disrupts the normal export process, causing an accumulation of these proteins within the nucleus. This accumulation can result in diverse biological effects.
KPT 330 (CAS 1393477-72-9) References
- KPT-330 has antitumour activity against non-small cell lung cancer. | Sun, H., et al. 2014. Br J Cancer. 111: 281-91. PMID: 24946002
- KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma. | Zheng, Y., et al. 2014. Cancer Chemother Pharmacol. 74: 487-95. PMID: 25030088
- Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer. | Kazim, S., et al. 2015. Mol Cancer Ther. 14: 1570-81. PMID: 25934708
- KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models. | Gravina, GL., et al. 2015. BMC Cancer. 15: 941. PMID: 26620414
- Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer. | Arango, NP., et al. 2017. Breast Cancer Res. 19: 93. PMID: 28810913
- KPT-330 inhibition of chromosome region maintenance 1 is cytotoxic and sensitizes chronic myeloid leukemia to Imatinib. | Nie, D., et al. 2018. Cell Death Discov. 4: 48. PMID: 29707241
- XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. | Zhu, ZC., et al. 2019. Cell Death Dis. 10: 395. PMID: 31113936
- KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway. | Dutta, P., et al. 2021. Circ Res. 128: 1300-1316. PMID: 33601919
- Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its Inhibitor. | Liu, S., et al. 2021. J Med Chem. 64: 15534-15548. PMID: 34669417
- Anti-tumor activity of the pan-RAF inhibitor TAK-580 in combination with KPT-330 (selinexor) in multiple myeloma. | Suzuki, R., et al. 2022. Int J Hematol. 115: 233-243. PMID: 34741230
- The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review. | Landes, JR., et al. 2022. J Cancer Res Clin Oncol.. PMID: 35941226
- Inhibition of XPO1 with KPT-330 induces autophagy-dependent apoptosis in gallbladder cancer by activating the p53/mTOR pathway. | Zhao, C., et al. 2022. J Transl Med. 20: 434. PMID: 36180918
- KPT-330 and Y219 exert a synergistic antitumor effect in triple-negative breast cancer through inhibiting NF-κB signaling. | Wen, T., et al. 2023. FEBS Open Bio. 13: 751-762. PMID: 36847599
Inhibitor of:
ATF-7, CIP29, CRM1, ENY2, Evx-1, EWS, Exportin 5, Exportin 6, Exportin 7, FAM184A, FMIP, Importin-12, Influenza A ns2, karyopherin α1, karyopherin α2, karyopherin β1, karyopherin β2, LRRC59, Med2p, MEDA-4, Mex67p, mrnp41, MYCBP, NIPA, NOL11, NOPAR, NTF2, Nucleoporin (NUP) Complex (NPC), Nup210L, NupL2, NXF7, NXT-1, Obox1, Olr1125, Olr113, Olr184, Olr659, p63, PAP-α, PAP-γ, PITHD1, POLR2J1, PRKRIP1, PSE1, PTH-rP, Ran BP-3, RBM23, RBM29, RBM7, RCC1, RHAMM, RNPS1, Sm B, Sm B′, SP140, SPT6, SUCO, TAF II p130, TAFII-18, TASK-2, TCEAL3, TCEAL5, TCEAL6, TFE3, THOC1, Trav12d-3, and ZNF593.Activator of:
CstF-50, Exportin 4, karyopherin β2, karyopherin β3, Nup155, RBMXL2, and TREX-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KPT 330, 5 mg | sc-489062 | 5 mg | $170.00 |