SULT2A7 Activators
Sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 7 activators are compounds that influence the availability of its substrates or enhance the enzyme's catalytic efficiency. Flavonoids such as quercetin, chrysin, naringenin, and apigenin inhibit UGTs, enzymes that conjugate glucuronic acid to substrates, this inhibition can lead to higher levels of DHEA, the preferred substrate for Sult2a7. Enhanced levels of DHEA directly lead to increased enzymatic activity by providing more substrate for Sult2a7 to act upon. Piperine and curcumin, by inhibiting various drug-metabolizing enzymes, can also elevate the levels of endogenous substrates for Sult2a7, indirectly enhancing the enzyme's activity.
Magnesium and zinc serve as cofactors or structural stabilizers for enzymes, including sulfotransferases. Adequate levels of these minerals ensure that Sult2a7 has the necessary cofactors for its catalytic action, thus enhancing its activity. Selenium, by maintaining the structural integrity of enzymes, plays a role in ensuring the functional stability of Sult2a7. Sulforaphane may upregulate the expression or stabilize Sult2a7, which would result in enhanced sulfotransferase activity. Finally, caffeine, by inhibiting certain metabolic pathways, may lead to an increase in DHEA, boosting thefunctional activity of Sult2a7.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits UGTs (UDP-glucuronosyltransferases), leading to increased availability of DHEA, a substrate for sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 7. This enhances the activity of Sult2a7 by providing more substrate to act upon. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine inhibits various drug-metabolizing enzymes, which can lead to elevated levels of endogenous substrates for Sult2a7, such as DHEA, thus enhancing Sult2a7 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to inhibit sulfation of other compounds, potentially leading to a compensatory increase in sulfotransferase activity. Sult2a7 could respond to this by enhancing its sulfating activity on available substrates such as DHEA. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavonoid that inhibits UGTs, thereby potentially increasing the concentration of DHEA. This increase in substrate availability can enhance the activity of Sult2a7. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc serves as an essential cofactor for many enzymes and may stabilize the structure of Sult2a7, enhancing its functional activity. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is crucial for maintaining the proper function of various enzymes. It can enhance the activity of Sult2a7 by ensuring its structural integrity and enzymatic function. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin, like quercetin and chrysin, is a flavonoid that can inhibit UGTs, leading to increased DHEA levels, which in turn can enhance the activity of Sult2a7. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is another flavonoid that inhibits UGTs, which could lead to higher DHEA availability, thereby enhancing the activity of Sult2a7. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol, can inhibit various enzymes involved in drug metabolism, potentially increasing the pool of DHEA, a substrate for Sult2a7, thus enhancing its activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can influence the expression of various phase II detoxification enzymes, including sulfotransferases. It may enhance the activity of Sult2a7 by upregulating its expression or by stabilizing the enzyme. | ||||||