STH1 Activators
STH1," or "SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 1," is a protein encoded by the SMARCA1 gene in humans. STH1 is a critical component of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodeling complex, which plays a pivotal role in regulating the structure and function of chromatin.Chromatin remodeling is a dynamic process where the structure of chromatin is modified to either compact or relax DNA. This alteration in chromatin structure is essential for controlling gene expression, as it regulates the accessibility of DNA to transcription factors and other proteins involved in DNA replication, repair, and recombination.
The SWI/SNF complex, including STH1, uses energy from ATP hydrolysis to slide, eject, or restructure nucleosomes, which are the basic units of chromatin. This action allows for the exposure or occlusion of specific gene sequences, thereby influencing gene expression patterns. STH1, in this complex, acts as an ATPase, providing the necessary energy for these remodeling activities.STH1's function in chromatin remodeling is crucial for various cellular processes, including development, differentiation, and response to environmental signals. Dysregulation of SWI/SNF complex activity, including alterations in STH1 function, has been implicated in the development of certain cancers and other diseases. This is because improper chromatin remodeling can lead to aberrant gene expression, contributing to the pathogenesis of these conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, Trichostatin A can indirectly influence chromatin remodeling, potentially affecting STH1 activity in the RSC complex. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can alter chromatin structure and indirectly impact STH1 function in chromatin remodeling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, SAHA, may affect chromatin structure, indirectly influencing STH1 activity. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A G9a histone methyltransferase inhibitor, BIX-01294, can alter histone methylation, potentially impacting STH1-mediated chromatin remodeling. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat, a Jumonji C domain-containing histone demethylase inhibitor, can indirectly influence STH1 activity by affecting histone methylation status. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A histone acetyltransferase inhibitor, C646 can indirectly affect STH1 function by influencing histone acetylation levels and chromatin structure. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
An HDAC3-specific inhibitor, RGFP966, may indirectly affect chromatin remodeling and STH1 function. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A histone methyltransferase inhibitor, specifically targeting SUV39H1, Chaetocin can indirectly influence STH1 activity in chromatin remodeling. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective HDAC inhibitor, MS-275, can indirectly influence STH1 function by altering chromatin structure. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, JQ1, indirectly impacts chromatin structure and can influence STH1 activity. | ||||||