Molecular structure of RGFP966, CAS Number: 1357389-11-7
RGFP966 (CAS 1357389-11-7)
Alternate Names:
(2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
CAS Number:
1357389-11-7
Molecular Weight:
362.4
Molecular Formula:
C21H19FN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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RGFP966 (CAS 1357389-11-7) References
- RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro. | Yu, X., et al. 2020. Drug Des Devel Ther. 14: 121-128. PMID: 32021097
- RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7. | Liang, H., et al. 2020. Biochem Pharmacol. 180: 114118. PMID: 32585142
- Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection. | Lei, L., et al. 2020. Toxicol Appl Pharmacol. 406: 115189. PMID: 32800772
- RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation. | Zheng, XH., et al. J Zhejiang Univ Sci B. 21: 703-715. PMID: 32893527
- RGFP966, a selective HDAC3 inhibitor, ameliorates allergic and inflammatory responses in an OVA-induced allergic rhinitis mouse model. | Zhang, W., et al. 2021. Int Immunopharmacol. 93: 107400. PMID: 33529911
- HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection. | Campo, M., et al. 2021. Tuberculosis (Edinb). 127: 102062. PMID: 33639591
- RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation. | Bian, HT., et al. 2021. Int Immunopharmacol. 101: 108259. PMID: 34666303
- RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats. | Gu, HP., et al. 2023. Heliyon. 9: e18160. PMID: 37539293
- HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression. | Zhang, L., et al. 2023. Redox Biol. 68: 102939. PMID: 37890360
- A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity. | Clayton, BLL., et al. 2024. Nat Neurosci. 27: 656-665. PMID: 38378993
Inhibitor of:
4632411B12Rik, A-Myb, A530032D15Rik, AIP4, Bdf1, BEND7, CAF-1 p150, CHD9, CREST, DPF3, ELP4, Gal11, Hat2, HDAC10, HDAC3, HDAC4, HDAC5, HiNF-P, His-probe, Histone cluster 1 H2AA, Histone cluster 1 H2AB, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H3H, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 2 H4B, Histone H2A, HLF, HUD, INTS10, INTS8, INTS9, mage-k1, MASGP-BP, MIER3, Morc, MORF, Msx-3, NOPAR, NTS12, OTTMUSG00000016779, Plectin, PRDM16, PSF, R3HDML, SAMD4B, SAP 25_Sap25, Sin4p, SMARCD2, Snf5, Sox-9, ST7, Sum1, TAF I p63_TAF I p68, TAF6L, THAP7, TMEM59, UBN-1, VPS72, WDR33, ZBP-89, Zfp13, ZFP563, ZKSCAN1, ZMYND12, ZMYND17, ZNF131, ZNF430, ZNF585A, ZNF588, ZNF606, ZNF764, ZNF806, and ZSCAN1.Activator of:
4930557A04Rik, ASCL2, Ataxin-1, CARM1, CHD2, CTDSPL2, DPPA4, EFO2, EG385328, EG434729, EG546205, EID-1, H2AL2, H2al2y, H2BFA, Histone cluster 1 H2AH, Histone cluster 1 H3J, Histone cluster 2 H2AB, Histone cluster 2 H2AC, Histone H2B, INO80B, Josephin-3, L3MBTL3, LANPL, MEAF6, Med10, Med11, Med19, MORF4L1, MRG15, NAP1L3, NSBP1, PABPC4, periphilin 1, RNF20, SA-2, SAP 18, SmcX, Spt7, SSU72, STH1, SYT, TADA3L, TAF II p43, TCF-19, TRAP100, YAF2, and ZSCAN18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RGFP966, 5 mg | sc-507300 | 5 mg | $115.00 |