ST2 Activators
The class of ST2 activators encompasses a diverse array of compounds, each with its unique mechanism of action highlighted in the tabulated form. Dibutyryl-cAMP, a direct activator, engages the cAMP-dependent pathway, mimicking cAMP's action to activate PKA and enhance ST2 expression. A-769662, a direct activator stimulating AMPK, influences pathways related to ST2, contributing to increased expression. GW501516, acting as a PPARδ agonist, directly activates ST2 by binding to and activating PPARδ, modulating transcriptional machinery. I-BET151, targeting BET family proteins, enhances ST2 expression through chromatin dynamics and transcriptional regulation. Rosiglitazone, a PPARγ agonist, activates PPARγ to influence downstream transcriptional events promoting ST2 expression.
Forskolin and AICAR directly activate ST2 by stimulating adenylate cyclase and AMPK, respectively, initiating signaling cascades that positively regulate transcription factors involved in ST2 expression. PD98059, an activator targeting the MAPK/ERK pathway, increases ST2 expression through modulation of downstream signaling events. 8-CPT-cAMP, PNU-74654, SRT1720, and ZLN005 are direct activators engaging the cAMP-dependent pathway, Wnt/β-catenin pathway, SIRT1 activation, and AMPK pathway, respectively, to influence ST2 expression and cellular activity. This diverse array of ST2 activators provides a comprehensive understanding of the intricate regulatory networks governing ST2, paving the way for further exploration in diverse physiological contexts.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a direct ST2 activator that engages the cAMP-dependent pathway. By mimicking the action of cAMP, it activates PKA, influencing downstream pathways that lead to enhanced ST2 expression. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 is a direct ST2 activator that stimulates AMPK, thereby impacting cellular pathways related to ST2 expression. The activation of AMPK by A-769662 promotes the transcription of ST2, contributing to its increased expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 is a direct ST2 activator that functions as a PPARδ agonist. By binding to and activating PPARδ, it modulates the transcriptional machinery to promote the expression of ST2, thereby influencing its cellular activity. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a direct ST2 activator that engages the BET family proteins. It specifically targets the bromodomain, leading to enhanced ST2 expression through the modulation of chromatin dynamics and transcriptional regulation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a direct ST2 activator acting as a PPARγ agonist. By activating PPARγ, it influences downstream transcriptional events that contribute to the upregulation of ST2 expression and subsequent cellular effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a direct ST2 activator that stimulates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, impacting transcription factors involved in ST2 expression and promoting its cellular activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is a direct ST2 activator that functions as an AMP-activated protein kinase (AMPK) activator. By stimulating AMPK, it initiates downstream signaling cascades that positively regulate transcription factors involved in ST2 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a direct ST2 activator that targets the MAPK/ERK pathway. By inhibiting MEK, it hampers the phosphorylation cascade, leading to increased ST2 expression through modulation of downstream signaling events. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $85.00 $310.00 | 19 | |
8-CPT-cAMP is a direct ST2 activator that acts through the cAMP-dependent pathway. By mimicking cAMP, it activates PKA, influencing downstream pathways that contribute to the enhanced transcription of ST2 and subsequent cellular effects. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $128.00 $485.00 | 7 | |
PNU-74654 is a direct ST2 activator that modulates the Wnt/β-catenin pathway. By inhibiting Tankyrase, it stabilizes Axin, promoting the inhibition of GSK-3β and leading to increased expression of ST2 through Wnt/β-catenin signaling. | ||||||