ST2 Activators

The class of ST2 activators encompasses a diverse array of compounds, each with its unique mechanism of action highlighted in the tabulated form. Dibutyryl-cAMP, a direct activator, engages the cAMP-dependent pathway, mimicking cAMP's action to activate PKA and enhance ST2 expression. A-769662, a direct activator stimulating AMPK, influences pathways related to ST2, contributing to increased expression. GW501516, acting as a PPARδ agonist, directly activates ST2 by binding to and activating PPARδ, modulating transcriptional machinery. I-BET151, targeting BET family proteins, enhances ST2 expression through chromatin dynamics and transcriptional regulation. Rosiglitazone, a PPARγ agonist, activates PPARγ to influence downstream transcriptional events promoting ST2 expression.

Forskolin and AICAR directly activate ST2 by stimulating adenylate cyclase and AMPK, respectively, initiating signaling cascades that positively regulate transcription factors involved in ST2 expression. PD98059, an activator targeting the MAPK/ERK pathway, increases ST2 expression through modulation of downstream signaling events. 8-CPT-cAMP, PNU-74654, SRT1720, and ZLN005 are direct activators engaging the cAMP-dependent pathway, Wnt/β-catenin pathway, SIRT1 activation, and AMPK pathway, respectively, to influence ST2 expression and cellular activity. This diverse array of ST2 activators provides a comprehensive understanding of the intricate regulatory networks governing ST2, paving the way for further exploration in diverse physiological contexts.