ST2 Antibody (14J07): sc-74296

ST2 Antibody (14J07) is a rat monoclonal IgG2a antibody that detects ST2 protein of mouse, rat, and human origin by western blotting (WB). Anti-ST2 antibody (14J07) is available as the non-conjugated format. ST2 protein, an orphan receptor belonging to the interleukin-1 receptor family, plays a crucial role in the immune response, particularly in the regulation of T helper cell type 2 (Th2) responses. ST2 expression is predominantly found on Th2 cells, which are essential for orchestrating allergic responses and combating parasitic infections. The gene encoding human ST2 is located on chromosome 2q12.1 and is regulated by two distinct promoters that facilitate transcription in different cell types, including hematopoietic cells and fibroblasts. ST2 undergoes alternative splicing to generate three distinct isoforms: the secreted soluble form (ST2S), which is produced by fibroblasts; the membrane-bound form (ST2L), which is expressed in hematopoietic cells; and ST2V, which is localized on the plasma membrane and found in the stomach, small intestine, and colon. The diverse expression patterns and functional roles of ST2 highlight potential as a therapeutic target for anti-inflammatory strategies, making ST2 monoclonal antibody (14J07) a valuable tool for researchers investigating immune modulation and related pathways.

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ST2 Antibody (14J07) References:

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2. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression.  |  Sweet, MJ., et al. 2001. J Immunol. 166: 6633-9. PMID: 11359817
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