ZLN005 (CAS 49671-76-3)
QUICK LINKS
ZLN005 is a small molecule activator of the transcriptional coactivator PGC-1α, a protein that is extensively studied for its role in regulating mitochondrial biogenesis and energy metabolism. In research applications, ZLN005 is used to investigate the molecular pathways involved in the regulation of metabolic processes within cells, particularly within muscle and adipose tissue. It has been instrumental in providing insights into the potential mechanisms for enhancing mitochondrial function, and it is often employed in studies aiming to understand the cellular responses to increased energy demands. Additionally, ZLN005′s ability to modulate PGC-1α activity makes it a useful compound for exploring the genetic and epigenetic factors that influence metabolic diseases. Researchers also utilize ZLN005 to study its potential effects on endurance and exercise performance at the cellular level, due to its implications in the regulation of genes associated with energy homeostasis.
ZLN005 (CAS 49671-76-3) References
- Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. | Zhang, LN., et al. 2013. Diabetes. 62: 1297-307. PMID: 23250358
- ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy. | Li, W., et al. 2016. Exp Cell Res. 345: 25-36. PMID: 27208585
- The PGC-1α Activator ZLN005 Ameliorates Ischemia-Induced Neuronal Injury In Vitro and In Vivo. | Xu, Y., et al. 2018. Cell Mol Neurobiol. 38: 929-939. PMID: 29159732
- Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage. | Satish, S., et al. 2018. Oxid Med Cell Longev. 2018: 9248640. PMID: 30524663
- Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition. | Cruz-Bermúdez, A., et al. 2019. Free Radic Biol Med. 135: 167-181. PMID: 30880247
- PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells. | Liu, Y., et al. 2020. Aging (Albany NY). 12: 7411-7430. PMID: 32343674
- PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury. | Yuan, L., et al. 2021. Aging (Albany NY). 13: 8421-8439. PMID: 33714196
- ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation. | Wang, Z., et al. 2021. Am J Transl Res. 13: 10014-10037. PMID: 34650679
- Pharmacologic induction of PGC-1α stimulates fetal haemoglobin gene expression. | Sun, Y., et al. 2022. Br J Haematol. 197: 97-109. PMID: 35118652
- ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis. | Zhu, P., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35455432
- PGC-1α attenuates TNF-α-induced inflammatory responses in OCCM-30 cells. | Fu, Y., et al. 2022. J Periodontal Res. 57: 1024-1033. PMID: 35903958
- ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes. | Suzuki, Y., et al. 2023. Front Immunol. 14: 1089905. PMID: 36820088
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZLN005, 5 mg | sc-474381A | 5 mg | $44.00 | |||
ZLN005, 10 mg | sc-474381 | 10 mg | $112.00 | |||
ZLN005, 25 mg | sc-474381B | 25 mg | $156.00 | |||
ZLN005, 50 mg | sc-474381C | 50 mg | $257.00 |