PNU-74654 (CAS 113906-27-7)
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PNU-74654 is a chemical that functions as a potent and selective inhibitor of the enzyme glycogen phosphorylase. It acts by binding to the allosteric site of the enzyme, thereby preventing the conversion of glycogen to glucose-1-phosphate. This inhibition ultimately leads to a decrease in glucose production and release from the liver, which may be useful for studying glycogen metabolism and its regulation. By targeting glycogen phosphorylase, PNU-74654 may be useful for investigate the role of this enzyme in various physiological and pathological conditions. At the molecular level, PNU-74654 disrupts the normal catalytic activity of glycogen phosphorylase, may provide a deeper understanding the regulatory mechanisms of glycogen metabolism. Its mode of action at the cellular level may be useful for understanding the biochemical pathways involved in glucose homeostasis and related metabolic disorders.
PNU-74654 (CAS 113906-27-7) References
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- Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. | Leal, LF., et al. 2015. Oncotarget. 6: 43016-32. PMID: 26515592
- PNU-74654 enhances the antiproliferative effects of 5-FU in breast cancer and antagonizes thrombin-induced cell growth via the Wnt pathway. | Rahmani, F., et al. 2019. J Cell Physiol. 234: 14123-14132. PMID: 30633353
- Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway. | Yang, T., et al. 2020. Exp Ther Med. 20: 1775-1781. PMID: 32742408
- Small Molecule Inhibitors of Microenvironmental Wnt/β-Catenin Signaling Enhance the Chemosensitivity of Acute Myeloid Leukemia. | Takam Kamga, P., et al. 2020. Cancers (Basel). 12: PMID: 32967262
- Inhibition of Aurora kinase A activity enhances the antitumor response of beta-catenin blockade in human adrenocortical cancer cells. | Maria, AG., et al. 2021. Mol Cell Endocrinol. 528: 111243. PMID: 33716050
- Shp2 suppresses fat accumulation in white adipose tissue by activating Wnt/β-catenin signaling following vertical sleeve gastrectomy in obese rats with type-2 diabetes. | Qi, X., et al. 2022. Exp Ther Med. 23: 302. PMID: 35340882
- PNU-74654 Suppresses TNFR1/IKB Alpha/p65 Signaling and Induces Cell Death in Testicular Cancer. | Chen, WJ., et al. 2022. Curr Issues Mol Biol. 44: 222-232. PMID: 35723395
- The Therapeutic Role of PNU-74654 in Hepatocellular Carcinoma May Involve Suppression of NF-κB Signaling. | Wu, MY., et al. 2022. Medicina (Kaunas). 58: PMID: 35744061
- Inhibition of the Wnt/b-catenin pathway using PNU-74654 reduces tumor growth in in vitro and in vivo models of colorectal cancer. | Amerizadeh, F., et al. 2022. Tissue Cell. 77: 101853. PMID: 35803035
- Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL. | Albalawi, YA., et al. 2022. Viruses. 14: PMID: 35891449
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNU-74654, 5 mg | sc-258020 | 5 mg | $128.00 | |||
PNU-74654, 25 mg | sc-258020A | 25 mg | $485.00 |