SSB-2 Activators
SSB-2 Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of SSB-2 through intricate cellular signaling mechanisms. Forskolin and IBMX, by increasing intracellular cAMP levels, activate protein kinase A (PKA), which may phosphorylate proteins that interact with SSB-2, effectively enhancing its signaling capacity. Phorbol 12-myristate 13-acetate (PMA) serves as a PKC activator, initiating a phosphorylation cascade that can include SSB-2 or its associated proteins, thereby amplifying its functional role in cellular communication.
Calcium ionophores like Ionomycin and A23187 increase intracellular calcium, which activates calcium-dependent kinases capable of modifying SSB-2's activity through phosphorylation. Spermine, through its influence on ion channels, may alter the ionic balance within cells, affecting SSB-2's activity indirectly. Epigallocatechin gallate (EGCG), by inhibiting certain protein kinases, can also shift phosphorylation patterns, potentially leading to enhanced SSB-2 function. Okadaic Acid, as an inhibitor of protein phosphatases PP1 and PP2A, prevents dephosphorylation, thereby maintaining proteins in a phosphorylated state that may be conducive to SSB-2 activation. Lastly, BAPTA-AM, by chelating calcium, influences calcium-dependent signaling pathways, which could result in an environment favoring SSB-2 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various substrates, thereby enhancing the activity of SSB-2 by promoting its interaction with signaling proteins that rely on phosphorylation status. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of substrates that interact with SSB-2, thus enhancing SSB-2's role in signal transduction. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may phosphorylate SSB-2 or associated proteins, thereby enhancing SSB-2 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, similar to Ionomycin, raising intracellular calcium and indirectly enhancing SSB-2 activity through calcium-dependent signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP levels, which in turn activate PKA. PKA can then enhance SSB-2 activity through phosphorylation of associated proteins. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that can modulate ion channels and may influence cellular signaling pathways that lead to the activation of SSB-2 by modulating the cellular ionic environment and thereby affecting protein interactions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases, potentially altering signaling pathways that can lead to the activation of SSB-2 by changing the phosphorylation dynamics of the protein and its interactors. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can result in increased phosphorylation levels of proteins within signaling pathways, potentially enhancing SSB-2 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeant calcium chelator that, upon intracellular hydrolysis, buffers calcium levels. This can indirectly influence calcium-dependent signaling pathways and thus enhance SSB-2 activity through the modulation of these pathways. | ||||||