SSB-2 Antibody (32-K): sc-100863

SSB-2 Antibody (32-K) is a mouse monoclonal IgG1 kappa light chain antibody that detects SSB-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SSB-2 antibody (32-K) is available as the non-conjugated format. SSB-2, also known as SplA/ryanodine (SPRY) receptor domain-containing SOCS box protein 2, plays a crucial role in cellular signaling pathways by interacting with various proteins, including Met, a receptor for hepatocyte growth factors. This interaction enhances hepatocyte growth factor signaling, which drives cell proliferation, survival, and migration. SSB-2 regulates protein degradation through its SOCS box, which mediates the association of SOCS proteins with the Elongin B and C complex. The SPRY domain in SSB-2 functions as a protein-protein interaction motif, emphasizing SSB-2′s importance in cellular communication and signaling networks. Mutations in genes encoding SPSB proteins, including SSB-2, have been linked to various human diseases, highlighting SSB-2′s relevance in health and disease.

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SSB-2 Antibody (32-K) References:

1. Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2).  |  Yao, S., et al. 2005. J Biomol NMR. 31: 69-70. PMID: 15692743
2. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.  |  Wang, D., et al. 2005. J Biol Chem. 280: 16393-401. PMID: 15713673
3. Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia.  |  Masters, SL., et al. 2005. Mol Cell Biol. 25: 5639-47. PMID: 15964819
4. The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues.  |  Masters, SL., et al. 2006. Nat Struct Mol Biol. 13: 77-84. PMID: 16369487
5. Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops.  |  Yao, S., et al. 2006. Protein Sci. 15: 2761-72. PMID: 17088318
6. Structural basis for protein recognition by B30.2/SPRY domains.  |  Woo, JS., et al. 2006. Mol Cell. 24: 967-76. PMID: 17189197
7. Twenty proteins containing a C-terminal SOCS box form five structural classes.  |  Hilton, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 114-9. PMID: 9419338

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SSB-2 Antibody (32-K) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SSB-2 Antibody (32-K) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SSB-2 Antibody (32-K) Specifications

Alternate Product Name: SSB-2

Product Clone Name: 32-K

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-91

Epitope Target: SSB-2

Epitope Species: human

Product Reactivity/Detection: SSB-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SSB-2 Antibody (32-K): N/A