SRRM5 Inhibitors
SRRM5 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of SRRM5 (Serine/Arginine Repetitive Matrix Protein 5), a protein involved in RNA splicing regulation. SRRM5 is part of the spliceosome complex, which plays a crucial role in the post-transcriptional modification of pre-mRNA, facilitating the removal of introns and the proper joining of exons. This splicing process allows for the production of multiple mRNA variants from a single gene, contributing to protein diversity. SRRM5 is thought to enhance alternative splicing, particularly influencing the inclusion or exclusion of specific exons, thereby regulating the expression of functionally distinct protein isoforms. Inhibitors of SRRM5 disrupt its role in RNA splicing, potentially leading to altered mRNA processing and changes in gene expression profiles.
The mechanism of action for SRRM5 inhibitors typically involves binding to the functional domains of the SRRM5 protein that are responsible for interacting with other spliceosomal components or with pre-mRNA substrates. By blocking these interactions, the inhibitors prevent SRRM5 from participating effectively in the splicing machinery, resulting in the misregulation of exon selection or even the failure to remove introns properly. This disruption can affect a wide range of cellular processes, as alternative splicing plays a critical role in generating the protein diversity required for normal cell function. Research into SRRM5 inhibitors provides valuable insights into the complexities of splicing regulation and the broader role of spliceosomal proteins in maintaining gene expression fidelity. Understanding how SRRM5 contributes to alternative splicing mechanisms can deepen our knowledge of the post-transcriptional control of gene expression and how these processes impact cellular and organismal development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, may downregulate SRRM5 by enhancing acetylation of histones near the SRRM5 gene, leading to an open chromatin state that paradoxically reduces promoter activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine can decrease methylation levels on the SRRM5 gene promoter, potentially leading to reduced transcription efficiency and lower protein expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could decrease SRRM5 levels by increasing histone acetylation, which although generally associated with transcription activation, may specifically disrupt promoter-specific transcription factor binding for SRRM5. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine may reduce SRRM5 expression by demethylating DNA regions upstream of the SRRM5 coding sequence, disrupting binding sites for transcriptional repressors and thereby reducing overall gene activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275′s inhibition of class I histone deacetylases could lead to condensed chromatin around the SRRM5 gene, effectively silencing its transcription and leading to decreased protein levels. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin may decrease SRRM5 expression by promoting the accumulation of acetylated histones, which disrupts the specific recruitment of transcription factors necessary for SRRM5 transcription. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
By inhibiting histone deacetylases, Mocetinostat could lead to a decrease in SRRM5 expression through enhanced acetylation and subsequent transcriptional repression mechanisms specific to the SRRM5 promoter. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat could downregulate SRRM5 by broadly increasing histone acetylation and inadvertently silencing genes through over-saturation of activating marks, which can interfere with normal transcriptional machinery. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat may inhibit SRRM5 expression by hyperacetylating histones at the gene locus, which can lead to non-specific binding of transcription factors and a general decrease in targeted gene transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
This compound may inhibit SRRM5 expression by disrupting the balance of histone acetylation, leading to a chromatin environment that is less conducive to the transcription of specific genes like SRRM5. | ||||||