SR-A Inhibitors
SR-A inhibitors belong to a distinctive chemical class of compounds designed to modulate the activity of Scavenger Receptor Class A (SR-A). SR-A is a type of cell surface receptor predominantly found on macrophages and other immune cells, and it plays a pivotal role in the innate immune response. These inhibitors are synthesized with the primary objective of regulating the function of SR-A and influencing cellular processes that are mediated by this receptor.
The chemical structure of SR-A inhibitors typically comprises a diverse range of organic molecules that exhibit specific binding affinities for SR-A. These compounds are carefully designed to interact with the receptor's ligand-binding domains, thereby preventing its engagement with its natural ligands. This interference can lead to a cascade of downstream effects, including the attenuation of phagocytosis and cytokine production. By modulating SR-A activity, these inhibitors hold the ability to impact various immune responses and inflammatory pathways, making them valuable tools for researchers exploring the intricate mechanisms of innate immunity and inflammation. Understanding the structural properties and binding affinities of SR-A inhibitors is crucial for elucidating their precise modes of action and applications in a variety of research contexts, such as immunology, cell biology, and molecular pharmacology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Acetylsalicylic acid, commonly known as aspirin, inhibits SR-A by blocking the activation of NF-κB, thus reducing inflammation and scavenger receptor expression. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin lowers SR-A expression by inhibiting the mevalonate pathway, leading to decreased cholesterol synthesis and reduced atherogenic lipid uptake by macrophages. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol modulates SR-A activity through anti-inflammatory and antioxidant effects, reducing oxidative stress and inflammation in macrophages. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol inhibits SR-A expression and activity by suppressing proinflammatory signaling pathways, including NF-κB, in macrophages. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene reduces SR-A-mediated foam cell formation by modulating estrogen receptors and downstream signaling pathways involved in lipid metabolism and inflammation. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, a PPAR-γ agonist, decreases SR-A expression by regulating lipid metabolism, insulin sensitivity, and inflammation in macrophages. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin inhibits SR-A expression and activity by downregulating NF-κB and MAPK pathways, resulting in reduced inflammation and oxidative stress in macrophages. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate, a PPAR-α agonist, decreases SR-A expression by enhancing lipid catabolism and reducing lipid accumulation, leading to reduced foam cell formation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin inhibits SR-A through its antioxidant and anti-inflammatory properties, reducing macrophage activation and foam cell formation by scavenging reactive oxygen species. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits SR-A expression by suppressing NF-κB activation and proinflammatory cytokine production in macrophages, mitigating atherosclerosis-related inflammation. | ||||||