SPT6 Inhibitors
SPT6 inhibitors target the SPT6 (Suppressor of Ty 6) protein. SPT6 is a highly conserved and essential protein found in eukaryotic cells, playing a critical role in the regulation of transcription and chromatin dynamics. It functions as a histone chaperone and is involved in several key processes related to gene expression and genome stability. SPT6 participates in the elongation phase of transcription, facilitating the movement of RNA polymerase II along the DNA template and ensuring proper chromatin structure by depositing histones onto newly synthesized DNA.
Inhibitors of SPT6 are designed to interact with this protein and potentially disrupt its various functions. These inhibitors may operate through mechanisms such as binding to specific domains of SPT6 or interfering with its interactions with other transcriptional and chromatin-associated factors. By inhibiting SPT6, these compounds can potentially impact the transcriptional process and chromatin structure, influencing the regulation of gene expression and genome stability. Research on SPT6 inhibitors is primarily focused on elucidating the molecular mechanisms by which SPT6 contributes to transcriptional regulation and chromatin dynamics, providing insights into the intricate processes governing gene expression and chromatin organization within the cell.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A cyclin-dependent kinase inhibitor that may indirectly reduce transcription of various genes, including SPT6. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
A natural product that inhibits translation and could potentially decrease protein levels of SPT6. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
An adenosine analogue that inhibits RNA polymerase II transcription, potentially reducing SPT6 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
A compound that intercalates into DNA and inhibits RNA polymerase, possibly reducing SPT6 mRNA synthesis. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A compound known to inhibit transcriptional activity, which could lower the expression of SPT6. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor that can alter gene expression profiles, possibly affecting SPT6 levels. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Another BET bromodomain inhibitor with the potential to disrupt transcription and reduce SPT6 expression. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
An exportin 1 inhibitor that could result in altered subcellular localization of transcription regulators, affecting SPT6 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inhibitor of N-linked glycosylation which can induce ER stress and affect gene expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can lead to altered protein turnover and affect gene expression patterns. | ||||||