SPT6 Activators
SPT6 activators indirectly promote the functional activity of SPT6, a protein implicated in transcription elongation and chromatin remodeling. Forskolin, by boosting intracellular cAMP levels, and Rolipram, through inhibiting cAMP breakdown, both enhance PKA activity, which could phosphorylate partners involved in transcription, potentially aiding SPT6's role in elongation. Trichostatin A and BIX-01294, by inhibiting histone deacetylase and G9a histone methyltransferase respectively, lead to an open chromatin state, thereby facilitating SPT6's access to DNA and enhancing its elongation capability. Similarly, 5-Azacytidine decreases DNA methylation, which may complement the function of SPT6 in promoting transcriptional activity. Caffeine's antagonistic effect on adenosine receptors might culminate in a cellular state that favors transcriptional processes where SPT6 is active, due to elevated cAMP levels.
Further contributing to the activation of SPT6 are compounds that affect the stability and interaction of transcriptional machinery. Isoquercetin and (-)-Epigallocatechin gallate, by modulating topoisomerase IIactivity and kinase activity respectively, could alleviate tension during transcription elongation and shift kinase-mediated signaling in favor of SPT6's function. SRT1720, by activating SIRT1, may enhance SPT6's chromatin-related activities through deacetylation of transcription factors. Lastly, SR8278 antagonizes REV-ERB, which may lead to the enhancement of SPT6's role in elongation by modulating circadian rhythms of gene expression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP activates PKA which can phosphorylate transcription factors, potentially enhancing the chromatin remodeling activity of SPT6. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, leads to a more acetylated and open chromatin state. This can enhance the transcription elongation role of SPT6 by facilitating its binding to histones. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, reduces DNA methylation, leading to a more transcriptionally active chromatin state which may indirectly enhance the transcriptional elongation activity of SPT6. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Isoquercetin, a flavonoid, is known to inhibit topoisomerase II. This can lead to reduced supercoiling tension during transcription elongation, which may enhance the function of SPT6 in this phase. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown. This indirectly supports the phosphorylation of transcription factors by PKA, possibly aiding the function of SPT6 in transcription elongation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine indirectly antagonizes adenosine receptors, which can lead to increased cAMP levels in cells, potentially enhancing the transcriptional elongation activity of SPT6 through PKA activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits several protein kinases, potentially shifting the equilibrium towards a state that favors transcriptional processes where SPT6 is active. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a G9a histone methyltransferase inhibitor, altering histone methylation patterns. This may facilitate transcriptional elongation mediated by SPT6. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SRT1720 activates SIRT1, leading to deacetylation of certain transcription factors, potentially enhancing the chromatin-related activities of SPT6. | ||||||
SR 8278 | 1254944-66-5 | sc-473353 | 10 mg | $344.00 | ||
SR8278 is a REV-ERB antagonist, which may lead to altered circadian regulation of transcription factors, possibly supporting the transcription elongation function of SPT6. | ||||||