Speedy E6 Activators
Speedy E6 Activators are diverse chemical compounds that indirectly influence the functional activity of Speedy E6 through various signaling pathways and cellular processes. Forskolin, by increasing intracellular cAMP levels, indirectly enhances Speedy E6's activity by promoting phosphorylation of downstream targets that may interact with Speedy E6, leading to its activation. Similarly, 8-Bromo-cAMP and IBMX indirectly augment Speedy E6 function by activating PKA and inhibiting phosphodiesterases, respectively, maintaining elevated cAMP levels that favor Speedy E6 activation. PMA, a potent PKC activator, and the calcium ionophores, Ionomycin and A23187, initiate intracellular signaling events that can lead to the phosphorylation and activation of proteins that are part of Speedy E6's signaling network. LY294002 and U0126, by inhibiting PI3K and MEK1/2 respectively, alter the balance of cellular signaling such that pathways involving Speedy E6 are indirectly enhanced.
Further, SB203580's inhibition of p38 MAPK may channel signaling events toward pathways that engage Speedy E6, potentially amplifying its role in cellular processes. Sildenafil and Zaprinast, through inhibition of phosphodiesterasesleading to increased cGMP levels, trigger signaling cascades that may indirectly activate Speedy E6 through interactions with cGMP-dependent protein kinases. Lastly, Bisindolylmaleimide I, though typically a PKC inhibitor, might indirectly promote Speedy E6 activation by causing changes in PKC-mediated regulatory pathways that could lead to compensatory mechanisms activating Speedy E6-related signaling. Collectively, these chemical activators, through their targeted effects on specific signaling molecules and pathways, facilitate the enhancement of Speedy E6 mediated functions without directly upregulating its expression or activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP may enhance the activity of Speedy E6 by promoting the phosphorylation of downstream targets that interact with Speedy E6, leading to its functional activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can result in the phosphorylation of proteins that may functionally interact with Speedy E6, indirectly enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX could indirectly increase Speedy E6 activity by sustaining the activation of its associated signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC activation can lead to the phosphorylation of substrates that may engage Speedy E6, resulting in the enhancement of its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially stimulating calcium-dependent protein kinases that could phosphorylate and activate proteins involved in the Speedy E6 signaling pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels, which could activate calcium-dependent pathways and proteins that interact with or support Speedy E6 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which may lead to altered signaling dynamics that indirectly enhance Speedy E6 activity by modulating associated pathways or relieving negative feedback mechanisms. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, leading to decreased ERK pathway activity. Altering ERK signaling could indirectly result in the activation of Speedy E6 by changing the activity of interacting proteins. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK could redirect signaling to pathways that involve Speedy E6, potentially enhancing its functional activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is another phosphodiesterase inhibitor, increasing cGMP levels, which could enhance Speedy E6 activity by engaging cGMP-dependent signaling pathways. | ||||||