SPEC1 Activators
SPEC1 Activators are a collection of chemical entities that facilitate the functional enhancement of SPEC1 through distinct and specific signaling mechanisms within the cell. Forskolin, by raising intracellular cAMP levels, activates protein kinase A (PKA), which may lead to the phosphorylation of substrates that interact with SPEC1, thereby enhancing its activity. Concurrently, the activation of protein kinase C (PKC) by compounds such as Phorbol 12-myristate 13-acetate (PMA) can modify the phosphorylation status of SPEC1 or associated proteins, indirectly augmenting SPEC1's functional capacity. Similar to this, Sphingosine-1-phosphate and Ionomycin both initiate cascades that culminate in the modulation of SPEC1 activity through cytoskeletal reorganization and calcium-dependent signaling, respectively. The action of polyphenols like Epigallocatechin gallate (EGCG) in inhibiting certain protein kinases could also shift cellular signaling dynamics to favor SPEC1 activation, especially if the inhibited kinases are upstream regulators of SPEC1.
Furthermore, compounds such as LY294002 and Wortmannin, which inhibit PI3K, could potentially relieve inhibitory control over SPEC1, assuming SPEC1 is negatively regulated by the PI3K/AKT pathway. Inhibitors like U0126 and SB203580, targeting MEK1/2 and p38 MAP kinase respectively, provide additional avenues for SPEC1 activation by affecting the ERK and MAPK signaling pathways, which may possess regulatory effects on SPEC1. Thapsigargin and A23187, by increasing intracellular calcium, can activate calcium-dependent proteins that may interact with or modify SPEC1, leading to its activation. Staurosporine, as a broad kinase inhibitor, might inadvertently disinhibit SPEC1 if the targeted kinases are part of a regulatory complex that suppresses SPEC1 activity under normal conditions. Together, these SPEC1 Activators operate through a multifaceted network of cellular signals and interactions, converging on the enhancement of SPEC1's role in the cell without necessitating changes in its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and enhance the activity of SPEC1 by promoting its proper folding and stabilization within the cellular environment, thus enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA functions as a potent activator of protein kinase C (PKC). PKC phosphorylation can lead to the activation of SPEC1 if SPEC1 is a substrate for PKC, or if PKC phosphorylation leads to changes in the cellular environment that favor SPEC1 activation, such as the alteration of membrane dynamics or interaction with specific cofactors. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate binds to its G protein-coupled receptors, initiating a signaling cascade that can lead to the activation of SPEC1. This might include the reorganization of the cytoskeleton or changes in cellular adhesion properties, which in turn could facilitate the activation or increased activity of SPEC1 in its respective pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that dramatically increases intracellular calcium levels. This rise in calcium can act as a second messenger in various signaling pathways, potentially leading to the activation of SPEC1 through calcium-dependent protein kinases or phosphatases that either directly modify SPEC1 or its interacting partners. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that has been observed to inhibit specific protein kinases. By inhibiting these kinases, EGCG could shift the signaling equilibrium in the cell to favor SPEC1 activation, if SPEC1 activity is enhanced by reduced phosphorylation from these targets or by the altered activity of signaling networks in which SPEC1 participates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. Inhibition of PI3K signaling can lead to a reduction in AKT activity, which might relieve negative feedback on SPEC1 if SPEC1 is negatively regulated by the PI3K/AKT pathway, thereby enhancing its functional activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in intracellular calcium levels. This can activate calcium-dependent signaling pathways that may enhance the activity of SPEC1 by promoting interactions with calcium-binding proteins or modification of SPEC1 itself. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. By inhibiting p38 MAPK, SB203580 could enhance SPEC1 activity if SPEC1 is part of a signaling cascade that is activated when p38 MAPK activity is low, or if p38 MAPK indirectly inhibits SPEC1 through phosphorylation of a third-party protein that interacts with SPEC1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels. This calcium influx can activate calcium-dependent enzymes that may directly or indirectly lead to the activation of SPEC1, for instance, by altering the phosphorylation state of SPEC1 or changing its interaction with other proteins. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Despite being a broad-spectrum protein kinase inhibitor, staurosporine could lead to the selective activation of SPEC1 pathways by lifting the inhibition exerted by specific kinases on SPEC1-related processes, if SPEC1's function is regulated by such kinases. | ||||||