SPANX-FI Inhibitors
The chemical class of SPANX-FI inhibitors encompasses a broad spectrum of compounds found in natural sources, such as plants, as well as synthetic molecules. These inhibitors exert their effects by targeting various signaling pathways implicated in inflammation and cancer progression. One key group of compounds within this class includes polyphenols, such as Curcumin, Resveratrol, and EGCG, which are abundant in fruits, vegetables, and beverages like green tea and red wine. Polyphenols have been extensively studied for their anti-inflammatory and anticancer properties, and they can inhibit SPANX-FI expression by modulating transcription factor activity, such as NF-κB and AP-1, thereby suppressing the transcription of genes associated with cancer development.
Another important subgroup of SPANX-FI inhibitors consists of flavonoids like Quercetin, Genistein, and Luteolin. Flavonoids are plant secondary metabolites with potent antioxidant and anti-inflammatory properties. They can inhibit SPANX-FI expression by interfering with estrogen receptor signaling and suppressing the activity of key transcription factors involved in inflammation and cancer progression. Additionally, certain inhibitors within this class, such as Celecoxib and Betulinic acid, target specific enzymes like COX-2 and AMPK, respectively, which are critical regulators of cellular processes associated with cancer development. By inhibiting these enzymes, these compounds can effectively suppress SPANX-FI expression and attenuate cancer cell growth.
Moreover, compounds like Sulforaphane and Thymoquinone belong to the class of SPANX-FI inhibitors known as bioactive phytochemicals. These compounds are characterized by their ability to activate cytoprotective pathways, such as the Nrf2 antioxidant response pathway, which plays a crucial role in regulating cellular redox balance and mitigating oxidative stress-induced inflammation and carcinogenesis. By activating Nrf2 and other cytoprotective pathways, these inhibitors can effectively inhibit SPANX-FI expression and modulate cancer cell behavior. Overall, the chemical class of SPANX-FI inhibitors represents a diverse array of compounds with multifaceted mechanisms of action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural polyphenolic compound found in turmeric. It has been shown to inhibit SPANX-FI expression by modulating various signaling pathways involved in inflammation and cancer progression, such as NF-κB and MAPK pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and red wine. It can inhibit SPANX-FI expression by activating SIRT1, a histone deacetylase that regulates gene expression and cellular processes associated with inflammation and cancer development. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy products. It can inhibit SPANX-FI expression by interfering with estrogen receptor signaling, which is implicated in the regulation of SPANX-FI expression and cancer progression in hormone-sensitive cancers such as breast cancer. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in various fruits and vegetables. It can inhibit SPANX-FI expression by suppressing the activity of transcription factors such as AP-1 and NF-κB, which are involved in the regulation of genes associated with inflammation and cancer development. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea. It can inhibit SPANX-FI expression by modulating signaling pathways such as PI3K/Akt and MAPK, which regulate gene expression and cellular processes associated with inflammation and cancer progression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid found in various plants. It can inhibit SPANX-FI expression by activating AMP-activated protein kinase (AMPK), which regulates cellular metabolism and energy homeostasis and has been implicated in the control of gene expression and cancer progression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a natural compound found in cruciferous vegetables. It can inhibit SPANX-FI expression by activating nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates genes involved in antioxidant defense and inflammation pathways. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone is a bioactive compound found in black seed oil. It can inhibit SPANX-FI expression by modulating various signaling pathways involved in inflammation and cancer progression, such as NF-κB and STAT3 pathways, which regulate the expression of genes associated with cancer development. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavonoid found in parsley, celery, and other plants. It can inhibit SPANX-FI expression by suppressing the activity of transcription factors such as NF-κB and AP-1, which regulate the expression of genes involved in inflammation and cancer progression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid is a pentacyclic triterpenoid found in various plants. It can inhibit SPANX-FI expression by activating AMP-activated protein kinase (AMPK) and inhibiting the PI3K/Akt/mTOR signaling pathway, which regulate cellular metabolism, growth, and survival, and have been implicated in cancer development. | ||||||