Sp4 Activators
The chemical class called Sp4 Activators encompasses a diverse set of compounds that can influence the activation of the transcription factor Sp4 through various mechanisms. These chemicals target specific signaling pathways or epigenetic processes, ultimately leading to increased Sp4 expression and transcriptional activity.
These activators act on pathways such as retinoic acid receptor signaling, cAMP/PKA signaling, histone acetylation via HDAC inhibition, AMPK activation, GSK-3 inhibition, DNA demethylation, Nrf2-Keap1 modulation, PI3K/Akt signaling, and ERK1/2 pathway activation. By affecting these pathways, the Sp4 activators create an environment that promotes Sp4-mediated gene transcription, contributing to the regulation of specific cellular processes and gene expression patterns.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can activate Sp4 by binding to retinoic acid receptors (RARs) and influencing the RAR signaling pathway, leading to increased Sp4 transcriptional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates Sp4 indirectly by elevating intracellular cAMP levels, which subsequently activates protein kinase A (PKA). PKA can phosphorylate and activate Sp4, enhancing its function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. By inhibiting HDACs, it can increase histone acetylation, promoting an open chromatin structure that facilitates Sp4 binding to its targets. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Sp4 through the AMP-activated protein kinase (AMPK) pathway. It can activate AMPK, which in turn can enhance Sp4 expression and activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It can demethylate the Sp4 promoter region, allowing for increased Sp4 gene expression and subsequent activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is an HDAC inhibitor that can promote histone acetylation, facilitating Sp4-mediated transcription through an epigenetic mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Sp4 indirectly by modulating the Nrf2-Keap1 pathway. It stabilizes Nrf2, which can enhance Sp4 expression and its transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates Sp4 by inhibiting glycogen synthase kinase-3 (GSK-3), leading to the stabilization and increased expression of Sp4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate Sp4 through the PI3K/Akt pathway. It can activate Akt, which in turn can phosphorylate and activate Sp4, promoting its transcriptional activity. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $78.00 | ||
Diallyl disulfide activates Sp4 through the ERK1/2 pathway. It can stimulate ERK1/2 phosphorylation, leading to enhanced Sp4-mediated gene transcription. | ||||||