Sox-7 Activators
The Sox-7 Activators class of chemicals comprises compounds that are capable of indirectly influencing the activity of the Sox-7 protein through their interaction with the Wnt/β-catenin and Notch signaling pathways. These chemicals include gamma-secretase inhibitors such as DAPT and DBZ, which block Notch signaling, leading to increased Sox-7 expression. On the other hand, GSK-3β inhibitors like LiCl, BIO, CHIR99021, and SB216763 activate the Wnt/β-catenin pathway, leading to enhanced Sox-7 activity due to its regulation by β-cateninThe second group of chemicals includes XAV-939, JW55, and IWR-1-endo, which are tankyrase inhibitors and Wnt response modulators.
These compounds stabilize Axin, a component of the β-catenin destruction complex, leading to the degradation of β-catenin. As Sox-7 is a known target of β-catenin, these compounds can indirectly influence Sox-7 activity. Lastly, ICG-001, PRI-724, and PNU-74654 are inhibitors of the interaction between β-catenin and its co-factors, CBP (CREB-binding protein) and Tcf (T-cell factor). As Sox-7 is regulated by β-catenin, these compounds can indirectly impact Sox-7 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a gamma-secretase inhibitor. It suppresses the cleavage of Notch, thereby inhibiting Notch signaling. This can increase Sox-7 expression, as Sox-7 is known to be repressed by active Notch signaling. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
DBZ is another gamma-secretase inhibitor that prevents the cleavage of Notch and suppresses Notch signaling. This can lead to the upregulation of Sox-7, as Notch signaling is known to repress Sox-7. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl is a GSK-3 beta inhibitor, which can result in the activation of the Wnt/β-catenin pathway. Sox-7 can be upregulated when this pathway is activated, as it is a known target of β-catenin. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a specific inhibitor of GSK-3β and can activate the Wnt/β-catenin pathway. This can result in an increase in Sox-7 activity, as Sox-7 is a target of β-catenin. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR99021 is another GSK-3β inhibitor, which can lead to the activation of the Wnt/β-catenin pathway. Sox-7, being a target of β-catenin, can be upregulated when this pathway is activated. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a potent inhibitor of GSK-3β and can activate the Wnt/β-catenin pathway. This can lead to increased Sox-7 activity, as Sox-7 is a known target of β-catenin. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a tankyrase inhibitor that stabilizes Axin, a component of the β-catenin destruction complex. This results in the degradation of β-catenin, indirectly impacting Sox-7 activity since it is a target of β-catenin. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 is a selective inhibitor of the PARP domain of tankyrase 1 and 2. This stabilizes Axin and promotes β-catenin degradation, which can indirectly affect Sox-7, a known target of β-catenin. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1-endo is a Wnt response modulator that stabilizes Axin and promotes β-catenin degradation. This can indirectly affect Sox-7 activity, as Sox-7 is a target of β-catenin. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is a selective inhibitor of the interaction between β-catenin and CBP. It can indirectly impact Sox-7 activity, as Sox-7 is a known target of β-catenin. | ||||||