Molecular structure of Dibenzazepine (Deshydroxy LY 411575), CAS Number: 209984-56-5
Dibenzazepine (Deshydroxy LY 411575) (CAS 209984-56-5)
See product citations (4)
Alternate Names:
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide γ-Secretase Inhibitor XX
Application:
Dibenzazepine (Deshydroxy LY 411575) is a dipeptidic (c)-secretase inhibitor
CAS Number:
209984-56-5
Purity:
98%
Molecular Weight:
463.48
Molecular Formula:
C26H23F2N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dibenzazepine (Deshydroxy LY 411575) is a dipeptidic gamma-secretase inhibitor which potently blocks Notch processing. The Notch pathway is a critical pathway that influences cell differentiation, proliferation, and apoptosis. Notch signaling is fundamental in the development and function of many organisms and tissues. By influencing this pathway, Dibenzazepine (Deshydroxy LY 411575) serves as a tool for researchers to dissect the complex roles of Notch signaling in cellular communication and development. Its utility extends to the study of tissue regeneration, developmental biology, and the dynamics of cell-to-cell communication.
Dibenzazepine (Deshydroxy LY 411575) (CAS 209984-56-5) References
- Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. | Weihofen, A., et al. 2000. J Biol Chem. 275: 30951-6. PMID: 10921927
- Identification of signal peptide peptidase, a presenilin-type aspartic protease. | Weihofen, A., et al. 2002. Science. 296: 2215-8. PMID: 12077416
- Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. | Kan, T., et al. 2004. Bioorg Med Chem Lett. 14: 1983-5. PMID: 15050642
- Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. | Krawitz, P., et al. 2005. J Biol Chem. 280: 39515-23. PMID: 15998642
- gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. | Tomita, T. and Iwatsubo, T. 2006. Curr Pharm Des. 12: 661-70. PMID: 16472155
- m6A modulates haematopoietic stem and progenitor cell specification. | Zhang, C., et al. 2017. Nature. 549: 273-276. PMID: 28869969
- NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin. | Katarkar, A., et al. 2020. Nat Commun. 11: 5126. PMID: 33046701
Inhibitor of:
Csl, ENHO, fringe, Gamma-secretase, GATA-5, GXYLT2, HES4, Jagged, Jagged1, karyopherin β2, KIAA1024L_A730017C20Rik, Manic Fringe, NET-7, Notch, Nrarp, NUMB, Olfr609, PCM1, PNP2, preY, Radical Fringe, RAM, RBP-Jκ, RBP-L, S-100A16, SEL-12, SLC35C2, TLE2, and TLE5.Activator of:
achaete, Aph-1b, C14orf135, D230039L06Rik, Delta, Deltex-4, DLN1, Hairless, HES7, HRT1_Hrt1, KIAA1024L_A730017C20Rik, LIN-31, Lunatic Fringe, MACS1, Mam1, Pecanex 2, PEN-2, POFUT1, Sox-7, and SPPL3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dibenzazepine (Deshydroxy LY 411575), 2 mg | sc-207554 | 2 mg | $235.00 | |||
Dibenzazepine (Deshydroxy LY 411575), 5 mg | sc-207554A | 5 mg | $260.00 |