SNX16 Activators
dNT-1 activators, known chemically as compounds influencing NT5C, play a crucial role in modulating the functional activity of dNT-1, a key enzyme in nucleoside metabolism. These activators primarily act by either serving as substrates for dNT-1 or by modifying the cellular nucleotide environment, thereby influencing the enzyme's activity. Substrates like Adenosine, Inosine, Deoxyadenosine, Deoxyinosine, and Guanosine directly enhance dNT-1's enzymatic activity by serving as necessary components for its metabolic processes. These nucleosides, integral to purine and pyrimidine metabolism, are directly acted upon by dNT-1, facilitating effective nucleotide breakdown and recycling. Furthermore, compounds such as Dipyridamole and Ribavirin influence dNT-1's activity indirectly. Dipyridamole, by inhibiting nucleoside transport, increases the intracellular availability of substrates for dNT-1, while Ribavirin, a guanosine analog, may serve as an alternative substrate, affecting dNT-1's substrate specificity and metabolism.
Additional activators like Pentostatin, Mycophenolate Mofetil, and Allopurinol modulate the nucleotide pool within cells, indirectly enhancing the functional role of dNT-1. Pentostatin, an adenosine deaminase inhibitor, increases adenosine levels, thus potentially enhancing dNT-1's role in adenosine metabolism. Mycophenolate Mofetil, by inhibiting inosine monophosphate dehydrogenase, and Allopurinol, a xanthine oxidase inhibitor, alter purine metabolism pathways, impacting dNT-1's activity. Furthermore, Methotrexate and Fludarabine, through their roles as a dihydrofolate reductase inhibitor and a nucleotide analog, respectively, affect purine synthesis and nucleotide metabolism, thereby indirectly influencing dNT-1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC), which plays a role in vesicle trafficking. Activation of PKC can enhance the recycling of endosomes, where SNX16 functions, thus potentially increasing the functional activity of SNX16. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3 kinase inhibitor. By inhibiting PI3K, it affects the phosphoinositide-dependent signaling pathway, which can alter the membrane trafficking routes that involve SNX16, leading to its functional enhancement. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts endosomal pH gradients. SNX16 has been associated with endosomal membrane trafficking; altering endosomal pH can enhance SNX16 functionality by affecting the endosomal sorting processes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase. When endosomal acidification is inhibited, it can lead to an increase in SNX16-associated endosomal sorting activity due to altered endosomal dynamics. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is known to inhibit clathrin-mediated endocytosis. By inhibiting this pathway, it could potentially increase the need for alternative endocytic pathways where SNX16 is active, thereby enhancing its function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor of dynamin which blocks clathrin-mediated endocytosis. This inhibition may reroute traffic through pathways that SNX16 regulates, indirectly enhancing its activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, affecting trafficking between endosomes and the trans-Golgi network, where SNX16 is implicated in sorting and trafficking, thereby potentially enhancing its function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization. Actin plays a critical role in the endocytic pathway and vesicular trafficking, so its inhibition can indirectly enhance SNX16 function by altering endosomal dynamics. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin terminal domain, affecting clathrin-mediated endocytosis. This inhibition can lead to an enhanced functional role for SNX16 in alternative endocytic pathways. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42 inhibitor; given that Cdc42 is involved in actin polymerization and vesicle trafficking, inhibition of Cdc42 may lead to an increased reliance on SNX16-mediated pathways. | ||||||