SMIM23 Activators
The activation mechanisms of SMIM23 are complex and involve various biochemical pathways influenced by specific activators. One such mechanism involves the elevation of intracellular cAMP through the direct stimulation of adenylate cyclase, which sets off a cascade of events culminating in the activation of protein kinase A (PKA). Once activated, PKA phosphorylates a variety of target proteins, potentially leading to the enhanced activity of SMIM23. Additionally, the activation of protein kinase C (PKC) through different biochemical agents results in the phosphorylation of proteins that may influence the functional capacity of SMIM23. PKC, known for its role in signaling cascades, can modify the activity of key proteins that closely interact with or regulate SMIM23 function. This interaction exemplifies how the modulation of one signaling molecule can have downstream effects on the activity of SMIM23.
Furthermore, intracellular calcium levels are another critical factor in the regulation of SMIM23 activity. Certain compounds can act as calcium ionophores, increasing the cytosolic concentration of calcium ions, which in turn may modulate the activity of calcium-dependent proteins and processes linked to SMIM23. This includes the potential facilitation of SMIM23 function through the activation of calcium-dependent kinases or phosphatases. Oxidative stress induced by reactive oxygen species can also modulate intracellular signaling pathways, which might influence the activity of SMIM23.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate target proteins affecting SMIM23's function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium, potentially facilitating SMIM23 function in calcium-dependent processes. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
β-adrenergic receptor agonist, elevating cAMP, possibly leading to SMIM23 activation through PKA signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that increases intracellular Ca²⁺, potentially modulating SMIM23 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases, leading to increased phosphorylation of proteins, which may affect SMIM23. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
cAMP analog that activates PKA, potentially enhancing SMIM23 phosphorylation and activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Modulates several signaling pathways and could enhance SMIM23 function by influencing membrane dynamics. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Donates nitric oxide, leading to cGMP increase, potentially enhancing SMIM23 activity via PKG activation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1 channels, leading to Ca²⁺ influx, which may indirectly increase SMIM23 function. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Modulates intracellular signaling pathways through oxidative stress, possibly affecting SMIM23 activity. | ||||||