SMEK1 Activators
SMEK1 Activators are distinct chemical entities that are designed to intensify the functional performance of SMEK1, a protein that plays a pivotal role in cellular processes including cell growth, apoptosis, and metabolism. These activators function through several direct and indirect pathways. Direct enhancement of SMEK1's functionality occurs through the inhibition of protein phosphatases such as PP2A, PP1, and PP4. Several compounds, including Epigallocatechin Gallate, Fostriecin, and Cantharidin, are potent inhibitors of these phosphatases. By inhibiting these phosphatases, they increase the overall phosphorylation, which can directly enhance the activation of SMEK1.
Indirect activators like Ionomycin, A23187, Forskolin, Isoprenaline, PMA, DAG, and cAMP operate by influencing various cellular processes that lead to the phosphorylation and activation of SMEK1. Ionomycin and A23187 increase intracellular calcium levels, activating calcium/calmodulin-dependent protein kinases (CaMKs) that can phosphorylate and activate SMEK1. Forskolin, Isoprenaline and cAMP increase cAMP levels, leading to the activation of Protein Kinase A (PKA). PKA can phosphorylate and activate SMEK1. PMA and DAG are potent activators of Protein Kinase C (PKC). PKC, like PKA and CaMKs, can phosphorylate and activate SMEK1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate (EGCG) inhibits PP2A, a phosphatase that dephosphorylates SMEK1. Inhibition of PP2A can result in enhanced phosphorylation and activation of SMEK1. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Fostriecin is a selective inhibitor of PP2A and PP4. By inhibiting these phosphatases, it can increase the phosphorylation and activation of SMEK1. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is a potent inhibitor of PP2A. By inhibiting PP2A, it can increase the phosphorylation and activation of SMEK1. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin increases intracellular calcium levels, which activates calcium/calmodulin-dependent protein kinases (CaMKs). CaMKs can phosphorylate and activate SMEK1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, activating CaMKs that can phosphorylate and activate SMEK1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and subsequently activating PKA. PKA can phosphorylate and activate SMEK1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoprenaline is a β-adrenergic receptor agonist which increases cAMP levels, leading to the activation of PKA. PKA can phosphorylate and activate SMEK1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC can phosphorylate and activate SMEK1. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DAG activates Protein Kinase C (PKC). PKC can phosphorylate and activate SMEK1. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP activates PKA. PKA can phosphorylate and enhance the activation of SMEK1. | ||||||