SMARCD2 Activators
SMARCD2 Activators, as a chemical class, predominantly fall within a realm of compounds that influence chromatin dynamics, notably the histone deacetylase inhibitors (HDAC inhibitors) and DNA methyltransferase inhibitors. Both categories act by altering the chromatin environment, thereby facilitating the recruitment or function of chromatin-remodeling complexes, including the SWI/SNF complex in which SMARCD2 is a component.
HDAC inhibitors, such as Trichostatin A, Vorinostat, Mocetinostat, Valproic Acid, Romidepsin, Panobinostat, Belinostat, Entinostat, and Givinostat, promote a more relaxed chromatin structure through the hyperacetylation of histones. This change in chromatin structure can lead to an environment where the SWI/SNF complex, and by extension SMARCD2, becomes more actively involved in repositioning nucleosomes and modulating gene expression. On the other hand, DNA methyltransferase inhibitors like 5-Azacytidine and Decitabine work by reducing the methylation levels of DNA. The consequent chromatin decondensation can pave the way for the SWI/SNF complex to carry out its chromatin-remodeling functions. Concurrently, Bromodomain inhibitor JQ1, by targeting BET family proteins, disrupts the reading of acetylated lysines on histones, thereby modifying the chromatin landscape. This alteration can necessitate the involvement of the SWI/SNF complex, emphasizing the functional role of SMARCD2 within the said complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor. Inhibiting HDACs promotes a relaxed chromatin structure. A relaxed chromatin environment might favor the recruitment or action of the SWI/SNF complex, indirectly promoting SMARCD2 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor. By reducing DNA methylation, it can lead to chromatin decondensation, potentially facilitating the recruitment and action of the SWI/SNF complex, and thus indirectly promoting SMARCD2 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor. By promoting hyperacetylation of histones, it can favor the SWI/SNF complex's function in repositioning nucleosomes. This may indirectly boost the functional role of SMARCD2 in the complex. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Bromodomain inhibitor. By targeting BET family proteins, it disrupts the reading of acetylated lysines on histones. This may alter the chromatin landscape in a way that might necessitate SWI/SNF activity, indirectly affecting SMARCD2. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
HDAC inhibitor. Its activity can alter the acetylation status of histones, potentially creating a chromatin environment that requires the action of the SWI/SNF complex, thereby indirectly influencing SMARCD2. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
HDAC inhibitor. Its ability to cause hyperacetylation of histones might pave the way for the SWI/SNF complex's action, indirectly promoting SMARCD2 function within the complex. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor. By altering DNA methylation patterns, it can create a need for the SWI/SNF complex to remodel chromatin, potentially indirectly activating SMARCD2. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
HDAC inhibitor. Changes in histone acetylation might require the action of the SWI/SNF complex for proper chromatin organization, potentially indirectly influencing SMARCD2's role. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
HDAC inhibitor. Altered histone acetylation might facilitate the requirement of the SWI/SNF complex for chromatin modification, possibly indirectly affecting SMARCD2 activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
HDAC inhibitor. Its function can create a chromatin environment that might benefit from the SWI/SNF complex's remodeling activity, potentially influencing SMARCD2 indirectly. | ||||||