SMARCD2 Antibody (F-34): sc-101162

SMARCD2 Antibody (F-34) is a mouse monoclonal IgG2a kappa light chain antibody that detects SMARCD2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SMARCD2 antibody (F-34) is available as the non-conjugated format. SMARCD2, also known as SWI/SNF related, matrix associated, Actin dependent regulator of chromatin, subfamily D, member 2, Rsc6p, PRO2451, or BAF60B, is a crucial component of the ATP-dependent chromatin remodeling complex SWI/SNF, which plays a significant role in gene expression regulation. SMARCD2 is primarily localized in the nucleus, where SMARCD2 participates in nucleosome remodeling, a process essential for transcription activation. The SWI/SNF complex, which includes SMARCD2, utilizes ATP to alter nucleosome structure, facilitating DNA access for transcription factors and other regulatory proteins. SMARCD2 serves as a vital component for proper gene regulation and cellular function. SMARCD2 is a homolog of yeast protein Swp73, necessary for transcriptional activation in Saccharomyces cerevisiae. Alternative splicing of SMARCD2 gene results in two isoforms, highlighting SMARCD2′s complexity and regulatory potential in various biological processes.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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SMARCD2 Antibody (F-34) References:

1. Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17.  |  Surabhi, RM., et al. 1999. Genome. 42: 545-9. PMID: 10382302
2. Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies.  |  Decristofaro, MF., et al. 2001. J Cell Physiol. 186: 136-45. PMID: 11147808
3. Influence of age, sex, and strength training on human muscle gene expression determined by microarray.  |  Roth, SM., et al. 2002. Physiol Genomics. 10: 181-90. PMID: 12209020
4. Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis.  |  Bo, H., et al. 2004. J Nippon Med Sch. 71: 172-80. PMID: 15226608
5. SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.  |  Priam, P., et al. 2017. Nat Genet. 49: 753-764. PMID: 28369034
6. Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.  |  Witzel, M., et al. 2017. Nat Genet. 49: 742-752. PMID: 28369036
7. Novel Frameshift Autosomal Recessive Loss-of-Function Mutation in SMARCD2 Encoding a Chromatin Remodeling Factor Mediates Granulopoiesis.  |  Yucel, E., et al. 2021. J Clin Immunol. 41: 59-65. PMID: 33025377
8. Clinical and transcriptomic characteristics of a novel SMARCD2 mutation that disrupts neutrophil maturation and function.  |  Dotta, L., et al. 2023. Pediatr Blood Cancer. 70: e30671. PMID: 37712719
9. Diversity and specialization of mammalian SWI/SNF complexes.  |  Wang, W., et al. 1996. Genes Dev. 10: 2117-30. PMID: 8804307
10. Gene structure of rat BAF60b, a component of mammalian SW1/SNF complexes, and its physical linkage to the growth hormone gene and transcription factor SUG/proteasome p45 gene.  |  Nomoto, K., et al. 1997. Gene. 202: 157-65. PMID: 9427560
11. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.  |  Ring, HZ., et al. 1998. Genomics. 51: 140-3. PMID: 9693044
12. Gene structure of rat testicular cell adhesion molecule 1 (TCAM-1), and its physical linkage to genes coding for the growth hormone and BAF60b, a component of SWI/SNF complexes.  |  Ono, M., et al. 1999. Gene. 226: 95-102. PMID: 9889334

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMARCD2 Antibody (F-34) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-SMARCD2 Antibody (F-34) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMARCD2 Antibody (F-34) Specifications

Alternate Product Name: SMARCD2

Product Clone Name: F-34

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 398-475

Epitope Target: SMARCD2

Epitope Species: human

Product Reactivity/Detection: SMARCD2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for SMARCD2 Antibody (F-34): N/A