SmarcAL1 Activators
SmarcAL1 Activators belong to a specialized chemical class that plays a crucial role in the regulation of gene expression within cells. These activators are primarily associated with modulating the activity of a specific protein known as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SmarcAL1), which is a critical component of chromatin remodeling complexes. Chromatin remodeling refers to the dynamic alteration of the structure and accessibility of DNA in the nucleus, allowing cells to tightly control gene transcription and gene expression. SmarcAL1 Activators exert their influence by directly interacting with SmarcAL1, thereby affecting its activity and ultimately influencing gene regulation.
At the molecular level, SmarcAL1 Activators are designed to bind to SmarcAL1, causing conformational changes in the protein that can either enhance or inhibit its function. This interaction can lead to the repositioning of nucleosomes (the structural units of chromatin), making specific regions of the DNA more or less accessible to the transcriptional machinery. By altering the accessibility of DNA, SmarcAL1 Activators can fine-tune the expression of genes, potentially turning them on or off in response to cellular signals and environmental cues. This dynamic regulation of gene expression is crucial for various cellular processes, including development, differentiation, and response to external stimuli. SmarcAL1 Activators, therefore, serve as important tools in the study of gene regulation mechanisms, allowing researchers to gain insights into the fundamental processes that govern cellular behavior.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP enhances SMARCAL1 activity by PKA-mediated phosphorylation, which can influence its role in DNA repair and replication. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By modifying chromatin structure, it may indirectly enhance the accessibility of SMARCAL1 to DNA substrates involved in repair processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of SMARCAL1, leading to increased protein stability and enhanced activity in DNA repair pathways. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine is known to induce hormonal and stress responses. It can indirectly enhance SMARCAL1 activity by stimulating DNA repair mechanisms where SMARCAL1 plays a role. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that creates DNA damage, which can subsequently increase the activity of SMARCAL1 in DNA repair pathways as a stress response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine affects lysosomal acidity and autophagy, which may indirectly increase the activity of SMARCAL1 by altering cellular stress responses where SMARCAL1 is involved. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is an ATM and ATR kinase inhibitor that can influence DNA damage response pathways, potentially enhancing SMARCAL1's role in homologous recombination and repair. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that induces DNA strand breaks. This drug indirectly enhances the activity of SMARCAL1 by activating DNA damage response processes. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to DNA replication stress. This can augment SMARCAL1 activity as it is recruited to replication forks under such stress. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor that stimulates the DNA damage response. It can indirectly boost SMARCAL1 activity by enhancing its role in the repair of DNA single-strand breaks. | ||||||