Slp2 Inhibitors
SLP2 inhibitors refer to a class of chemical compounds that have been designed and studied for their capacity to modulate the activity or expression of SLP2 (Stomatin-Like Protein 2). SLP2, also known as STOML2 (Stomatin-Like Protein 2), is a membrane protein primarily found in the mitochondria and is known to play multifaceted roles in cellular processes, particularly those related to mitochondrial function, lipid metabolism, and cellular responses to stress. SLP2 is of particular interest to researchers because of its implication in mitochondrial homeostasis and its potential relevance to various cellular processes.
Inhibitors of SLP2 are chemical compounds designed to interact with SLP2 directly or indirectly, either by modulating its expression levels or influencing its cellular functions. These inhibitors can be small molecules or targeted agents that interfere with SLP2's interactions with other proteins, its subcellular localization, or its post-translational modifications. Researchers have been exploring these inhibitors to gain a better understanding of the precise roles that SLP2 plays in cellular physiology and to uncover potential links between SLP2 dysregulation and various diseases or conditions. By inhibiting SLP2, scientists aim to dissect the functional consequences of altered SLP2 activity, shedding light on its involvement in processes such as mitochondrial dynamics, lipid metabolism, and stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may induce hyperacetylation of histones, leading to a conformational change in chromatin that could result in the downregulation of Slp2 transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By causing demethylation of DNA, 5-Azacytidine could lead to the repression of gene promoters that drive the transcription of the Slp2 gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin might diminish the translation of upstream regulators of Slp2 through inhibition of the mTOR pathway, resulting in reduced synthesis of Slp2. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may elevate lysosomal pH, potentially disrupting the endosomal trafficking of transcription factors necessary for Slp2 gene transcription, thereby decreasing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid could repress Slp2 transcription by altering the transcriptional activity of retinoic acid receptors that bind to the Slp2 promoter region. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By inhibiting MEK1/2, PD 98059 may prevent the phosphorylation and activation of transcription factors that are crucial for Slp2 mRNA synthesis, leading to diminished expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could inhibit the PI3K/AKT signaling cascade, which may be necessary for the transcriptional initiation of Slp2, thus leading to its decreased expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 may block TGF-β signaling, potentially leading to downregulation of transcriptional activators or co-activators essential for Slp2 gene expression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 could decrease Slp2 expression by inhibiting the ROCK kinase pathway, which may play a role in the control of gene transcription machinery for Slp2. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib may lead to an accumulation of ubiquitinated proteins, thereby sequestering ubiquitin-proteasome system components and indirectly leading to reduced transcription of Slp2. | ||||||