SLC43A3 Inhibitors
Chemicals classified as SLC43A3 Inhibitors encompass a range of compounds that can indirectly alter the function or expression of the SLC43A3 protein. SLC43A3 is a solute carrier, and while there are no direct inhibitors, various agents that perturb energy metabolism, cellular trafficking, and ionic gradients can modulate the activity or localization of this protein. Metformin and Phenformin, by activating AMPK, can lead to the downregulation of mTOR signaling, which is a master regulator of cell growth and metabolism. Such regulation can affect SLC43A3's role in cellular processes that depend on energy status.
On the other hand, agents like Niclosamide, Oligomycin, 2-Deoxy-D-glucose, FCCP, Rotenone, and Antimycin A disrupt mitochondrial function and glycolysis, leading to altered ATP production and cellular energy balance. The resulting energy stress can impact the function of solute carriers such as SLC43A3 by limiting their ability to utilize ATP or by changing the cell's metabolic priorities. Furthermore, compounds like Actinonin, which affects protein synthesis, and Chloroquine, Brefeldin A, and Monensin, which interfere with intracellular trafficking and ionic gradients, can lead to changes in SLC43A3 trafficking, expression, or activity. These chemicals, through their diverse mechanisms, create a cellular environment that can indirectly influence the function of SLC43A3, which is crucial for the transport of specific solutes across cellular membranes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $117.00 | 4 | |
Like Metformin, activates AMPK with similar potential effects on SLC43A3-related signaling. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Uncouples mitochondrial oxidative phosphorylation, which can disrupt energy metabolism and indirectly influence SLC43A3. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Inhibits ATP synthase, potentially affecting ATP levels and altering SLC43A3 function due to energy depletion. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Glycolysis inhibitor that can decrease energy production, indirectly affecting SLC43A3 activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
Protonophore uncoupling agent, can disrupt proton gradients, possibly affecting SLC43A3-related transport processes. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Inhibits mitochondrial electron transport chain, potentially affecting cellular energy status and SLC43A3 function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Inhibits complex III of the electron transport chain, similarly affecting energy status and potentially SLC43A3 activity. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Peptide deformylase inhibitor, can affect protein synthesis and potentially alter SLC43A3 expression or function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to alter endosomal and lysosomal pH, potentially disrupting cellular trafficking routes involving SLC43A3. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Inhibits ADP-ribosylation factor, can disrupt Golgi apparatus function, potentially impacting SLC43A3 trafficking. | ||||||